Hampton David W, Anderson Jane, Pryce Gareth, Irvine Karen-Amanda, Giovannoni Gavin, Fawcett James W, Compston Alastair, Franklin Robin J M, Baker David, Chandran Siddharthan
Cambridge Centre for Brain Repair, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 2PY. UK.
J Neuroimmunol. 2008 Sep 15;201-202:200-11. doi: 10.1016/j.jneuroim.2008.05.034. Epub 2008 Jul 30.
Multiple sclerosis (MS) represents a considerable challenge to experimentally model due to its twin pathologies of inflammatory demyelination and neurodegeneration along with its multifocal and multiphasic nature. Experimental autoimmune encephalomyelitis (EAE) in Biozzi ABH mice has previously been shown to reproduce many clinical features also found in secondary progressive MS. In this study we sought to characterise the pathology of chronic EAE in ABH mice. In addition to marked gliosis, we report substantial demyelination, remyelination and axonal and neuronal loss. Together with the clinical pattern, our findings identify chronic EAE as an excellent model of secondary progressive multiple sclerosis.
多发性硬化症（MS）对实验建模来说是一项相当大的挑战，因为它具有炎症性脱髓鞘和神经退行性变这两种病理特征，同时还具有多灶性和多相性。先前已证明，Biozzi ABH小鼠的实验性自身免疫性脑脊髓炎（EAE）能重现继发进展型MS中出现的许多临床特征。在本研究中，我们试图描述ABH小鼠慢性EAE的病理学特征。除了明显的胶质细胞增生外，我们还报告了大量的脱髓鞘、髓鞘再生以及轴突和神经元丢失。结合临床模式，我们的研究结果表明慢性EAE是继发进展型多发性硬化症的一个优秀模型。
