Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia.
Department of Histology and Embriology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Front Immunol. 2020 Jun 3;11:947. doi: 10.3389/fimmu.2020.00947. eCollection 2020.
A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of blockade of IL-17 secreted by autoreactive T cells has been shown in various inflammatory diseases. Several cytokines, whose production is affected by environmental factors, control Th17 differentiation and its maintenance in tissues during chronic inflammation. The roles of IL-17 in the pathogenesis of chronic neuroinflammatory conditions, multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), Alzheimer's disease, and ischemic brain injury are reviewed here. The role of environmental stimuli in Th17 differentiation is also summarized, highlighting the role of viral infection in the regulation of pathogenic T helper cells in EAE.
IL-17 是辅助性 T 细胞 17（Th17）细胞产生的一种细胞因子，其在慢性炎症和自身免疫性疾病的发病机制中起着关键作用。阻断自身反应性 T 细胞分泌的 IL-17 已被证明对多种炎症性疾病具有积极作用。几种细胞因子的产生受环境因素的影响，可控制 Th17 分化及其在慢性炎症时在组织中的维持。本文综述了 IL-17 在慢性神经炎症性疾病（如多发性硬化症、实验性自身免疫性脑脊髓炎、阿尔茨海默病和缺血性脑损伤）发病机制中的作用。还总结了环境刺激在 Th17 分化中的作用，突出了病毒感染在调节 EAE 中致病性辅助性 T 细胞中的作用。
