Danila Delia C, Wang Xinyan, Hubble Heather, Antipin Igor S, Pinkhassik Eugene
Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA.
Bioorg Med Chem Lett. 2008 Apr 1;18(7):2320-3. doi: 10.1016/j.bmcl.2008.02.081. Epub 2008 Mar 6.
A series of aminophosphonates was synthesized, and their ability to carry alanine, a model hydrophilic molecule, across phospholipid bilayer membranes was evaluated. Aminophosphonates facilitate the membrane transport at moderate rates, which make them a suitable platform for the design of carriers for continuous drug release devices.
合成了一系列氨基膦酸盐，并评估了它们携带亲水性模型分子丙氨酸穿过磷脂双分子层膜的能力。氨基膦酸盐以适度的速率促进膜运输，这使其成为设计用于持续药物释放装置的载体的合适平台。
