Canto Marcia Irene
Department of Medicine (Gastroenterology), Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, 1830 East Monument Street, Baltimore, MD 21205, USA.
Gastrointest Endosc Clin N Am. 2008 Jul;18(3):535-53, x. doi: 10.1016/j.giec.2008.05.012.
Screening and surveillance for pancreatic cancer and its precursors is a relatively new indication for endoscopic ultrasound. It provides an alternative approach to the ineffective treatment of mostly incurable symptomatic pancreatic cancer. It is currently reserved for individuals with an increased risk for pancreatic ductal adenocarcinoma, such as those who have inherited genetic syndromes (eg, patients who have Peutz-Jeghers syndrome or hereditary pancreatitis, germline mutation carriers of p16 and BRCA2) and at-risk relatives of patients who have familial pancreatic cancer. This article discusses the rationale for performing screening and surveillance, the types of patients who are eligible for screening, the diagnostic modalities and technique for screening, the diagnostic yield of screening, and the ongoing research.
胰腺癌及其癌前病变的筛查和监测是内镜超声一项相对较新的应用指征。它为大多数无法治愈的症状性胰腺癌的无效治疗提供了一种替代方法。目前，它适用于胰腺导管腺癌风险增加的个体，例如那些患有遗传性综合征（如患有黑斑息肉综合征或遗传性胰腺炎的患者、p16和BRCA2基因种系突变携带者）以及家族性胰腺癌患者的高危亲属。本文讨论了进行筛查和监测的基本原理、适合筛查的患者类型、筛查的诊断方式和技术、筛查的诊断率以及正在进行的研究。
