Kwon Hyun Ae, Kwon Yong-Jun, Kwon Dong-Yeul, Lee John Hwa
College of Veterinary Medicine, Chonbuk National University, Jeonju, 561-756, Republic of Korea.
Int J Food Microbiol. 2008 Sep 30;127(1-2):180-3. doi: 10.1016/j.ijfoodmicro.2008.06.020. Epub 2008 Jun 29.
The antibacterial potential of a preparation of medicinal herbs for the treatment of salmonellosis was evaluated. The preparation contained a combination of methanolic extracts from Mume Fructus, Coptidis Rhizoma and Schizandrae Fructus, and is designated NP532. NP532 was tested against 26 different Salmonella stains. All these strains were affected by NP532 even though many of the salmonella strains were resistant to multiple antibiotics. The MIC values of this combination against the Salmonella strains varied from 0.49 to 7.8 mg/ml. The in vivo antibacterial activity of NP532 was examined using a S. Gallinarum infection chicken model. The chickens were initially infected with S. Gallinarum, and NP532 was then administered. This preparation was found to have major effects on mortality. The histopathological observations of the NP532 treated animals did not show any of the clinical signs and rarely showed histological damage associated with the disease. On the other hand, the untreated controls showed the clinical signs, e.g. congestion and necrotic changes in the liver, kidney, and spleen. This suggests that NP532 might be an effective treatment for salmonellosis.
对一种用于治疗沙门氏菌病的草药制剂的抗菌潜力进行了评估。该制剂含有乌梅、黄连和五味子的甲醇提取物组合，命名为NP532。NP532针对26种不同的沙门氏菌菌株进行了测试。尽管许多沙门氏菌菌株对多种抗生素耐药，但所有这些菌株都受到NP532的影响。该组合对沙门氏菌菌株的最低抑菌浓度值在0.49至7.8毫克/毫升之间。使用鸡感染鸡白痢沙门氏菌模型检测了NP532的体内抗菌活性。鸡最初感染鸡白痢沙门氏菌，然后给予NP532。发现该制剂对死亡率有显著影响。经NP532处理的动物的组织病理学观察未显示任何临床症状，很少显示与疾病相关的组织学损伤。另一方面，未处理的对照组出现了临床症状，如肝脏、肾脏和脾脏的充血和坏死变化。这表明NP532可能是治疗沙门氏菌病的有效药物。
