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厚朴酚及其含药提取物的化学与生物活性研究进展。

Advances in Chemistry and Bioactivity of Magnoflorine and Magnoflorine-Containing Extracts.

机构信息

Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1 St., 20-093 Lublin, Poland.

Department of Pharmacognosy, Medical University of Lublin, Chodzki 1 St., 20-093 Lublin, Poland.

出版信息

Int J Mol Sci. 2020 Feb 16;21(4):1330. doi: 10.3390/ijms21041330.

Abstract

The review collects together some recent information on the identity and pharmacological properties of magnoflorine, a quaternary aporphine alkaloid, that is widely distributed within the representatives of several botanical families like Berberidaceae, Magnoliaceae, Papaveraceae, or Menispermaceae. Several findings published in the scientific publications mention its application in the treatment of a wide spectrum of diseases including inflammatory ones, allergies, hypertension, osteoporosis, bacterial, viral and fungal infections, and some civilization diseases like cancer, obesity, diabetes, dementia, or depression. The pharmacokinetics and perspectives on its introduction to therapeutic strategies will also be discussed.

摘要

该综述收集了一些关于广泛分布在小檗科、木兰科、罂粟科或防己科等几个植物科代表物中的季铵型阿朴啡生物碱——蝙蝠葛碱的身份和药理学特性的最新信息。一些已发表在科学出版物中的研究结果提到了它在治疗各种疾病中的应用,包括炎症、过敏、高血压、骨质疏松症、细菌、病毒和真菌感染,以及一些文明病,如癌症、肥胖、糖尿病、痴呆或抑郁症。本文还将讨论其药代动力学及其在治疗策略中的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f904/7072879/6103b91e7a9d/ijms-21-01330-g001.jpg

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