Batistatou Anna, Charalabopoulos Konstantinos, Nakanishi Yukihiro, Vagianos Constantine, Hirohashi Setsuo, Agnantis Niki J, Scopa Chrissoula D
Department of Pathology, University of Ioannina Medical School, University Campus, P.O. Box 1186, 451 10, Ioannina, Greece.
Endocr Pathol. 2008 Fall;19(3):197-202. doi: 10.1007/s12022-008-9035-1.
Dysadherin is a novel glycoprotein, with an anti-cell-cell adhesion function. The aim of the present study was to examine the expression of dysadherin in thyroid papillary microcarcinoma (PMC), to associate it with the expression of E-cadherin and to investigate whether there are differences with papillary carcinoma (PC). A statistically significant difference in dysadherin and E-cadherin expression between PC and PMC and a negative correlation between E-cadherin and dysadherin expression regardless of tumor size were noted. Based on these findings it is hypothesized that retained cell-cell adhesion, through maintenance of the E-cadherin adhesion system, in PMC prevents neoplastic cells from dissociating easily from each other and metastasizing. Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherin downregulation in thyroid papillary neoplasia.
粘连失调蛋白是一种新型糖蛋白，具有抗细胞间粘附功能。本研究的目的是检测粘连失调蛋白在甲状腺微小乳头状癌（PMC）中的表达，将其与E-钙粘蛋白的表达相关联，并研究其与乳头状癌（PC）是否存在差异。结果发现，PC和PMC之间粘连失调蛋白和E-钙粘蛋白的表达存在统计学显著差异，且无论肿瘤大小，E-钙粘蛋白和粘连失调蛋白的表达呈负相关。基于这些发现，推测在PMC中通过维持E-钙粘蛋白粘附系统来保留细胞间粘附，可防止肿瘤细胞彼此轻易解离和转移。粘连失调蛋白表达增加可能是甲状腺乳头状瘤形成过程中E-钙粘蛋白下调的转录后机制之一。
