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给狗接种抗细粒棘球绦虫疫苗:控制包虫病的一种手段?

Vaccination of dogs against Echinococcus granulosus: a means to control hydatid disease?

作者信息

Zhang Wenbao, McManus Donald P

机构信息

Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4006, Australia.

出版信息

Trends Parasitol. 2008 Sep;24(9):419-24. doi: 10.1016/j.pt.2008.05.008. Epub 2008 Aug 3.

Abstract

Hydatid disease continues to be a substantial cause of morbidity and mortality worldwide. Elimination is difficult with current control options, but reducing egg production by Echinococcus granulosus (Eg) in canines might help to reduce transmission in areas where the parasite is endemic. Recently obtained data using recombinant protein-based and live attenuated Salmonella vaccines are preliminary but encouraging and auger well for the future development of an effective dog vaccine against Eg, although much additional work is required before this becomes a reality. New approaches to control and for the prevention of hydatidosis have been described recently, and important additional gains should be expected if the efficacy of the dog vaccines is confirmed and leads to their incorporation into future control options.

摘要

包虫病仍然是全球发病和死亡的一个重要原因。目前的控制措施难以消除该病,但减少犬类细粒棘球绦虫(Eg)的产卵量可能有助于减少寄生虫流行地区的传播。最近使用基于重组蛋白的和减毒活沙门氏菌疫苗获得的数据虽然是初步的,但令人鼓舞,为开发一种有效的抗Eg犬用疫苗的未来发展带来了希望,不过在这成为现实之前还需要大量额外工作。最近已经描述了控制和预防包虫病的新方法,如果犬用疫苗的有效性得到证实并导致其被纳入未来的控制措施中,预计会有重要的额外收获。

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