Cook J K, Holmes H C, Finney P M, Dolby C A, Ellis M M, Huggins M B
AFRC Institute for Animal Health, Houghton Laboratory, Houghton, Huntingdon, Cambridgeshire, England.
Avian Pathol. 1989 Jul;18(3):523-34. doi: 10.1080/03079458908418624.
An attenuated turkey rhinotracheitis (TRT) vaccine strain, when given either by eye drop or by aerosol, has been shown to be effective in protecting 1- to 11-day-old turkey poults against an experimental challenge with TRTV up to 14 weeks later. TRT antibody-free poults and poults hatched from TRT-immune dams were both equally well protected, although a high proportion of the latter did not respond serologically to the vaccine. As little as 1 CD50 of vaccine was found to be effective in protecting poults against challenge. Immunity developed within about 6 days of vaccination of 7-day-old TRT antibody-free poults and humoral antibody persisted for at least 14 weeks after a single vaccination at 4 weeks of age.
一种减毒的火鸡鼻气管炎（TRT）疫苗株，通过滴眼或气雾方式接种时，已证明能有效保护1至11日龄的火鸡雏免受TRTV的实验性攻击，长达14周。无TRT抗体的雏鸡和由TRT免疫母禽孵化出的雏鸡均得到了同等良好的保护，尽管后者中有很大比例在血清学上对疫苗无反应。发现仅1个CD50的疫苗就能有效保护雏鸡免受攻击。对7日龄无TRT抗体的雏鸡接种疫苗后，约6天内产生免疫力，在4周龄时单次接种后，体液抗体至少持续14周。
