反流性食管炎患者的喉咽反流
Laryngopharyngeal reflux in patients with reflux esophagitis.
作者信息
Lai Yung-Chih, Wang Pa-Chun, Lin Jun-Chen
机构信息
Department of Internal Medicine, Cathay General Hospital, Taiwan, China.
出版信息
World J Gastroenterol. 2008 Jul 28;14(28):4523-8. doi: 10.3748/wjg.14.4523.
AIM
To assess the prevalence of laryngopharyngeal reflux (LPR) in patients with reflux esophagitis and disclose factors contributing to the development of LPR.
METHODS
A total of 167 patients who proved to have reflux esophagitis by endoscopy were enrolled. They received laryngoscopy to grade the reflux findings for the diagnosis of LPR. We used validated questionnaires to identify the presence of laryngopharyngeal symptoms, and stringent criteria of inclusion to increase the specificity of laryngoscopic findings. The data of patients were analyzed statistically to find out factors related to LPR.
RESULTS
The prevalence rate of LPR in studied subjects with reflux esophagitis was 23.9%. Age, hoarseness and hiatus hernia were factors significantly associated with LPR. In 23 patients with a hiatus hernia, the group with LPR was found to have a lower trend of esophagitis grading.
CONCLUSION
Laryngopharyngeal reflux is present in patients with reflux esophagitis, and three predicting factors were identified. However, the development of LPR might be different from that of reflux esophagitis. The importance of hiatus hernia deserves further study.
目的
评估反流性食管炎患者喉咽反流（LPR）的患病率，并揭示导致LPR发生的因素。
方法
共纳入167例经内镜检查证实患有反流性食管炎的患者。他们接受喉镜检查以对反流表现进行分级，用于诊断LPR。我们使用经过验证的问卷来确定喉咽症状的存在，并采用严格的纳入标准以提高喉镜检查结果的特异性。对患者数据进行统计学分析，以找出与LPR相关的因素。
结果
在研究的反流性食管炎患者中，LPR的患病率为23.9%。年龄、声音嘶哑和食管裂孔疝是与LPR显著相关的因素。在23例患有食管裂孔疝的患者中，发现有LPR的组食管炎分级有较低趋势。
结论
反流性食管炎患者存在喉咽反流，并确定了三个预测因素。然而，LPR的发生可能与反流性食管炎不同。食管裂孔疝的重要性值得进一步研究。
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