Shih Chih-Wei, Yang Chung-May, Chen Muh-Shy, Wang Tsung-Jen
Department of Ophthalmology, National Taiwan University Hospital and School of Medicine, National Taiwan University, 7, Chung Shan South Rd., Taipei, Taiwan.
Graefes Arch Clin Exp Ophthalmol. 2008 Nov;246(11):1547-51. doi: 10.1007/s00417-008-0902-8. Epub 2008 Aug 6.
To report the effect of intravitreal injection of bevacizumab and gas for the treatment of diabetic premacular hemorrhage with active fibrovascular proliferation.
Six eyes of six consecutive patients with acute diabetic premacular hemorrhage and active fibrovascular proliferation received intravitreal injection of bevacizumab (1.25 mg in 0.05 mL) and C3F8 (0.2-0.3 mL) during the same setting. All six cases had panretinal photocoagulation prior to the procedure. After treatment, patients maintained a prone position for 3 days and were followed for an average of 8 months (range, 4-13 months).
All six eyes had complete reabsorption of the hemorrhage and reduction of fibrovascular proliferation. Transient vitreous opacification from breakthrough of the blood were observed in all eyes. An average of 3.8 weeks (range, 1-6 weeks) was required for the clearing of preretinal hemorrhage. Visual acuity improved in all six eyes. No recurrent bleeding or other adverse events were encountered in all cases.
Intravitreal injection of bevacizumab and gas may be an effective method for treating acute diabetic premacular hemorrhage with active fibrovascular proliferation.
报告玻璃体内注射贝伐单抗联合气体治疗伴有活跃纤维血管增生的糖尿病性黄斑前出血的效果。
连续6例患有急性糖尿病性黄斑前出血且伴有活跃纤维血管增生的患者的6只眼，在同一次治疗中接受了玻璃体内注射贝伐单抗（0.05 mL中含1.25 mg）和C3F8（0.2 - 0.3 mL）。所有6例患者在手术前均接受了全视网膜光凝治疗。治疗后，患者保持俯卧位3天，并平均随访8个月（范围4 - 13个月）。
所有6只眼的出血均完全吸收，纤维血管增生减轻。所有眼中均观察到因血液突破导致的短暂性玻璃体混浊。视网膜前出血清除平均需要3.8周（范围1 - 6周）。所有6只眼的视力均有改善。所有病例均未出现复发性出血或其他不良事件。
玻璃体内注射贝伐单抗联合气体可能是治疗伴有活跃纤维血管增生的急性糖尿病性黄斑前出血的有效方法。
