Entringer Sonja, Kumsta Robert, Nelson Edward L, Hellhammer Dirk H, Wadhwa Pathik D, Wüst Stefan
Department of Psychobiology, University of Trier, Johanniterufer 15, Trier, Germany.
Dev Psychobiol. 2008 Sep;50(6):579-87. doi: 10.1002/dev.20316.
The aim of the present study was to determine the association between prenatal stress and immune function in human adults. Peripheral blood mononuclear cells (PBMCs) from 34 healthy young women whose mothers experienced major negative life events during their pregnancy (Prenatal Stress, PS group, mean age 25, SD +/- 4.34 years), and from a female comparison group (n = 28, CG, mean age 24 +/- 3.40 years), were stimulated with phytohemagglutinin (PHA), and subsequent cytokine production was measured. A bias for T-helper 2 (Th2) cytokine production due to an overproduction of IL-4 relative to IFN-gamma after PHA stimulation was observed in PS subjects. In addition, IL-6 and IL-10 were also significantly elevated. To the best of our knowledge, this study is the first to suggest a direct association between prenatal stress exposure and alterations in immune parameters in adult women.
本研究的目的是确定成年人体内产前应激与免疫功能之间的关联。采集了34名健康年轻女性（其母亲在孕期经历了重大负面生活事件，即产前应激组，PS组，平均年龄25岁，标准差±4.34岁）以及一个女性对照组（n = 28，CG组，平均年龄24±3.40岁）的外周血单个核细胞（PBMC），用植物血凝素（PHA）进行刺激，并检测随后的细胞因子产生情况。在PS组受试者中观察到，PHA刺激后，由于白细胞介素-4（IL-4）相对于干扰素-γ（IFN-γ）过度产生，导致辅助性T细胞2（Th2）细胞因子产生存在偏差。此外，白细胞介素-6（IL-6）和白细胞介素-10（IL-10）也显著升高。据我们所知，本研究首次表明产前应激暴露与成年女性免疫参数改变之间存在直接关联。
