Skopińska-Rózewska E, Malinowski M, Wasiutyński A, Sommer E, Furmanowa M, Mazurkiewicz M, Siwicki A K
Department of Pathology, Biostructure Center, Medical University, Warsaw, Poland.
Pol J Vet Sci. 2008;11(2):97-104.
The genus Rhodiola (Crassulaceae) consists of more than 100 species. They grow mainly in Tibet, China and Mongolia and are traditionally used as tonic, adaptogen, antidepressant and anti-inflammatory drugs. The best known is Rhodiola rosea (R. rosea) now cultivated also in Europe and North America, and present on the market as dietary supplement. Some authors reported anti-tumor activity of R. rosea extracts. Recently, we have published some data on immunomodulatory and antiangiogenic properties of R. rosea. Rhodiola quadrifida (R. quadrifida) belongs to the same family, but is almost not known in Europe, and there is no information about its possible anti-tumor as well as immunotropic and angiotropic activity. The aim of this study was to determine the influence of 50% hydro-alcoholic extract from rhizomes of R. quadrifida (Mongolian origin) and its main biologically active compound salidroside on tumor-induced angiogenesis. Angiogenesis was induced in the skin of Balb/c mice by grafting of syngeneic L-1 sarcoma cells. Mice were fed R. quadrifida extract or salidroside in daily doses 40, 200 and 400 microg, or 0.5, 1, 2, and 4 microg, respectively. After 72 hours, mice were sacrificed with lethal dose of Morbital. All newly formed blood vessels were identified and counted in dissection microscope.
It was found that R. quadrifida extract and salidroside highly significantly decreased neovascular reaction in all doses applied.
红景天属（景天科）由100多个物种组成。它们主要生长在中国西藏、蒙古，传统上用作滋补品、适应原、抗抑郁药和抗炎药。最著名的是红景天，目前在欧洲和北美也有种植，并作为膳食补充剂投放市场。一些作者报道了红景天提取物的抗肿瘤活性。最近，我们发表了一些关于红景天免疫调节和抗血管生成特性的数据。四裂红景天属于同一科，但在欧洲几乎无人知晓，也没有关于其可能的抗肿瘤以及免疫亲和性和血管亲和性活性的信息。本研究的目的是确定来自蒙古的四裂红景天根茎的50%水醇提取物及其主要生物活性化合物红景天苷对肿瘤诱导的血管生成的影响。通过移植同基因L-1肉瘤细胞在Balb/c小鼠皮肤中诱导血管生成。小鼠分别以每日剂量40、200和400微克或0.5、1、2和4微克喂食四裂红景天提取物或红景天苷。72小时后，用致死剂量的戊巴比妥处死小鼠。在解剖显微镜下识别并计数所有新形成的血管。
发现四裂红景天提取物和红景天苷在所有应用剂量下均高度显著降低新生血管反应。
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