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红景天苷抗癌作用的研究进展。

Advances in Research on Anticancer Properties of Salidroside.

机构信息

Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, China.

The College of Post and Telecommunication, Wuhan Institute of Technology, Wuhan, 430073, China.

出版信息

Chin J Integr Med. 2021 Feb;27(2):153-160. doi: 10.1007/s11655-020-3190-8. Epub 2020 Mar 6.

DOI:10.1007/s11655-020-3190-8
PMID:32144560
Abstract

Salidroside is a phenolic secondary metabolite present in plants of the genus Rhodiola, and studies investigating its extensive pharmacological activities and mechanisms have recently attracted increasing attention. This review summarizes the progress of recent research on the antiproliferative activities of salidroside and its effects on breast, ovarian, cervical, colorectal, lung, liver, gastric, bladder, renal, and skin cancer as well as gliomas and fibrosarcomas. Thus, it provides a reference for the further development and utilization of salidroside.

摘要

红景天苷是植物红景天属中存在的酚类次生代谢产物,其广泛的药理活性和作用机制的研究近年来受到越来越多的关注。本文综述了近年来关于红景天苷的抗增殖活性及其对乳腺癌、卵巢癌、宫颈癌、结直肠癌、肺癌、肝癌、胃癌、膀胱癌、肾癌和皮肤癌以及神经胶质瘤和纤维肉瘤的影响的研究进展。因此,为红景天苷的进一步开发和利用提供了参考。

相似文献

1
Advances in Research on Anticancer Properties of Salidroside.红景天苷抗癌作用的研究进展。
Chin J Integr Med. 2021 Feb;27(2):153-160. doi: 10.1007/s11655-020-3190-8. Epub 2020 Mar 6.
2
Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties.红景天苷:对其合成途径和药理性质最新进展的综述。
Chem Biol Interact. 2021 Apr 25;339:109268. doi: 10.1016/j.cbi.2020.109268. Epub 2021 Feb 20.
3
[Advance in studies on pharmacological effect of salidroside on nervous system diseases].红景天苷对神经系统疾病药理作用的研究进展
Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2505-9.
4
Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase.红景天和红景天苷对糖尿病的有益作用:AMP 激活的蛋白激酶的潜在作用。
Mol Diagn Ther. 2019 Aug;23(4):489-498. doi: 10.1007/s40291-019-00402-4.
5
Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy.红景天提取物和红景天苷通过抑制 mTOR 通路和诱导自噬来抑制膀胱癌细胞系的生长。
Mol Carcinog. 2012 Mar;51(3):257-67. doi: 10.1002/mc.20780. Epub 2011 Apr 22.
6
Salidroside, the main active compound of Rhodiola plants, inhibits high glucose-induced mesangial cell proliferation.红景天苷是红景天属植物的主要活性成分,可抑制高糖诱导的系膜细胞增殖。
Planta Med. 2009 Sep;75(11):1191-5. doi: 10.1055/s-0029-1185717. Epub 2009 May 14.
7
In vivo Th1 and Th2 cytokine modulation effects of Rhodiola rosea standardised solution and its major constituent, salidroside.红景天标准溶液及其主要成分红景天苷对体内 Th1 和 Th2 细胞因子的调节作用。
Phytother Res. 2011 Nov;25(11):1604-11. doi: 10.1002/ptr.3451. Epub 2011 Mar 11.
8
Complete Pathway Elucidation and Heterologous Reconstitution of Rhodiola Salidroside Biosynthesis.全面阐明和异源重建红景天苷的生物合成途径。
Mol Plant. 2018 Jan 8;11(1):205-217. doi: 10.1016/j.molp.2017.12.007. Epub 2017 Dec 20.
9
The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3.红景天苷对柯萨奇病毒B3的体内外抗病毒作用
Phytomedicine. 2009 Mar;16(2-3):146-55. doi: 10.1016/j.phymed.2008.07.013. Epub 2008 Sep 24.
10
Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells.红景天苷诱导人乳腺癌细胞周期停滞和凋亡。
Biochem Biophys Res Commun. 2010 Jul 16;398(1):62-7. doi: 10.1016/j.bbrc.2010.06.033. Epub 2010 Jun 10.

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Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma.调节miRNA治疗骨肉瘤的天然产物研究进展
Biology (Basel). 2025 Jan 13;14(1):61. doi: 10.3390/biology14010061.
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Salidroside Pre-Treatment Inhibits Hypertensive Renal Injury and Fibrosis Through Inhibiting Wnt/β-Catenin Pathway.红景天苷预处理通过抑制Wnt/β-连环蛋白信号通路减轻高血压肾损伤和纤维化
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Characteristics of the vaginal microbiota and vaginal metabolites in women with cervical dysplasia.

本文引用的文献

1
Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway.红景天苷通过抑制 Notch1 信号通路的激活抑制肝癌细胞的转移。
Mol Med Rep. 2019 Jun;19(6):4964-4972. doi: 10.3892/mmr.2019.10115. Epub 2019 Apr 2.
2
Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP-9 signaling pathways in human bladder cancer cells.红景天苷对人膀胱癌细胞的抗癌作用通过自噬/PI3K/Akt和MMP-9信号通路降低细胞活力。
Oncol Lett. 2018 Sep;16(3):3162-3168. doi: 10.3892/ol.2018.8982. Epub 2018 Jun 18.
3
Salidroside inhibits migration, invasion and angiogenesis of MDA‑MB 231 TNBC cells by regulating EGFR/Jak2/STAT3 signaling via MMP2.
宫颈发育不良女性的阴道微生物群特征和阴道代谢产物。
Front Cell Infect Microbiol. 2024 Oct 10;14:1457216. doi: 10.3389/fcimb.2024.1457216. eCollection 2024.
4
The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside.GLCCI1/STAT3 通路:参与糖尿病认知功能障碍的新通路及红景天苷的治疗作用。
J Mol Histol. 2024 Oct;55(5):851-861. doi: 10.1007/s10735-024-10236-y. Epub 2024 Aug 29.
5
Salidroside inhibited the proliferation of gastric cancer cells through up-regulating tumor suppressor miR-1343-3p and down-regulating MAP3K6/MMP24 signal molecules.红景天苷通过上调肿瘤抑制因子miR-1343-3p和下调MAP3K6/MMP24信号分子来抑制胃癌细胞的增殖。
Cancer Biol Ther. 2024 Dec 31;25(1):2322206. doi: 10.1080/15384047.2024.2322206. Epub 2024 Mar 4.
6
Directed Evolution of 4-Hydroxyphenylpyruvate Biosensors Based on a Dual Selection System.基于双选择系统的 4-羟基苯丙酮酸生物传感器的定向进化。
Int J Mol Sci. 2024 Jan 26;25(3):1533. doi: 10.3390/ijms25031533.
7
Phenolic Compounds of L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases.山黧豆中酚类化合物有望成为治疗慢性疾病的替代疗法。
Int J Mol Sci. 2023 Jul 31;24(15):12293. doi: 10.3390/ijms241512293.
8
Salidroside suppresses the multiple oncogenic activates and immune escape of lung adenocarcinoma through the circ_0009624-mediated PD-L1 pathway.红景天苷通过 circ_0009624 介导的 PD-L1 通路抑制肺腺癌的多种致癌激活和免疫逃逸。
Thorac Cancer. 2023 Aug;14(24):2493-2503. doi: 10.1111/1759-7714.15034. Epub 2023 Jul 9.
9
Erythropoietin mediates re-programming of endotoxin-tolerant macrophages through PI3K/AKT signaling and protects mice against secondary infection.促红细胞生成素通过 PI3K/AKT 信号转导介导内毒素耐受巨噬细胞的重编程,并保护小鼠免受二次感染。
Front Immunol. 2022 Aug 9;13:938944. doi: 10.3389/fimmu.2022.938944. eCollection 2022.
10
Salidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting Inflammation and Apoptosis.红景天苷通过抑制炎症和凋亡保护脓毒症大鼠急性肾损伤。
Drug Des Devel Ther. 2022 Mar 30;16:899-907. doi: 10.2147/DDDT.S361972. eCollection 2022.
红景天苷通过调节 MMP2 抑制 EGFR/Jak2/STAT3 信号通路抑制 MDA-MB-231 TNBC 细胞的迁移、侵袭和血管生成。
Int J Oncol. 2018 Aug;53(2):877-885. doi: 10.3892/ijo.2018.4430. Epub 2018 Jun 5.
4
Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis.红景天苷通过抑制炎症和促进细胞凋亡预防 DMBA/TPA 诱导的小鼠皮肤癌变。
Oncol Rep. 2018 Jun;39(6):2513-2526. doi: 10.3892/or.2018.6381. Epub 2018 Apr 18.
5
Salidroside induces apoptosis in human ovarian cancer SKOV3 and A2780 cells through the p53 signaling pathway.红景天苷通过p53信号通路诱导人卵巢癌SKOV3和A2780细胞凋亡。
Oncol Lett. 2018 May;15(5):6513-6518. doi: 10.3892/ol.2018.8090. Epub 2018 Feb 21.
6
Salidroside could enhance the cytotoxic effect of L‑OHP on colorectal cancer cells.红景天苷可增强 L-OHP 对结直肠癌细胞的细胞毒性作用。
Mol Med Rep. 2018 Jan;17(1):51-58. doi: 10.3892/mmr.2017.7846. Epub 2017 Oct 20.
7
Rhodiola plants: Chemistry and biological activity.红景天属植物:化学与生物活性。
J Food Drug Anal. 2015 Sep;23(3):359-369. doi: 10.1016/j.jfda.2015.04.007. Epub 2015 May 29.
8
Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics.姜黄素通过活性氧介导的DNA聚合酶γ耗竭破坏细胞生物能量学来抑制胃肿瘤细胞生长。
J Exp Clin Cancer Res. 2017 Mar 31;36(1):47. doi: 10.1186/s13046-017-0513-5.
9
Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway.红景天苷通过抑制PI3K/Akt/mTOR通路诱导人结肠癌细胞凋亡和自噬。
Oncol Rep. 2016 Dec;36(6):3559-3567. doi: 10.3892/or.2016.5138. Epub 2016 Sep 30.
10
Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells.RLIP76的下调与人类结直肠癌HCT-8/VCR细胞中的长春新碱耐药性相关。
Int J Oncol. 2016 Oct;49(4):1505-1512. doi: 10.3892/ijo.2016.3672. Epub 2016 Aug 23.