迷迭香叶：在衰老相关疾病中的潜在应用。
Rosenroot (): Potential Applications in Aging-related Diseases.
作者信息
Zhuang Wei, Yue Lifeng, Dang Xiaofang, Chen Fei, Gong Yuewen, Lin Xiaolan, Luo Yumin
机构信息
1Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
2Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
出版信息
Aging Dis. 2019 Feb 1;10(1):134-146. doi: 10.14336/AD.2018.0511. eCollection 2019 Feb.
Abstract
Aging is a progressive accumulation of changes in the body, which increases the susceptibility to diseases such as Alzheimer's disease, Parkinson's disease, cerebrovascular disease, diabetes, and cardiovascular disease. Recently, Chinese medicinal herbs have been investigated for their therapeutic efficacy in the treatment of some aging-related diseases. , known as 'Hongjingtian' in Chinese, has been reported to have anti-aging activity. Here, we provide a comprehensive review about its origin, chemical constituents, and effects on aging-related diseases.
摘要
衰老乃是机体变化的渐进性积累，这会增加患阿尔茨海默病、帕金森病、脑血管疾病、糖尿病及心血管疾病等病症的易感性。近来，人们对中草药治疗某些与衰老相关疾病的疗效进行了研究。红景天，其在中文里被称作“Hongjingtian”，据报道具有抗衰老活性。在此，我们对其来源、化学成分以及对与衰老相关疾病的影响进行全面综述。
相似文献
1
Rosenroot (): Potential Applications in Aging-related Diseases.迷迭香叶：在衰老相关疾病中的潜在应用。
Aging Dis. 2019 Feb 1;10(1):134-146. doi: 10.14336/AD.2018.0511. eCollection 2019 Feb.
2
Anti-inflammatory effects of Rhodiola rosea L.: A review.红景天的抗炎作用：综述。
Biomed Pharmacother. 2020 Jan;121:109552. doi: 10.1016/j.biopha.2019.109552. Epub 2019 Nov 9.
3
Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole time-of-flight mass spectrometry.液相色谱-四极杆飞行时间质谱法对红景天注射液化学成分的表征
Biomed Chromatogr. 2019 Mar;33(3):e4446. doi: 10.1002/bmc.4446. Epub 2018 Dec 6.
4
Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy.红景天与阿尔茨海默病：从农场到药房
Phytother Res. 2016 Apr;30(4):532-9. doi: 10.1002/ptr.5569. Epub 2016 Jan 11.
5
The authenticity and quality of Rhodiola rosea products.红景天产品的真伪与质量。
Phytomedicine. 2016 Jun 15;23(7):754-62. doi: 10.1016/j.phymed.2015.10.006. Epub 2015 Oct 31.
6
Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.罗森罗特（红景天）：传统用途、化学成分、药理学和临床疗效。
Phytomedicine. 2010 Jun;17(7):481-93. doi: 10.1016/j.phymed.2010.02.002. Epub 2010 Apr 7.
7
Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: an interactive pathway analysis of the downstream effects using RNA microarray data.红景天、红景天苷、酪醇和三萜醇在分离的神经胶质细胞中的作用机制：利用RNA微阵列数据对下游效应进行交互通路分析
Phytomedicine. 2014 Sep 25;21(11):1325-48. doi: 10.1016/j.phymed.2014.07.008. Epub 2014 Aug 7.
8
Complete Pathway Elucidation and Heterologous Reconstitution of Rhodiola Salidroside Biosynthesis.全面阐明和异源重建红景天苷的生物合成途径。
Mol Plant. 2018 Jan 8;11(1):205-217. doi: 10.1016/j.molp.2017.12.007. Epub 2017 Dec 20.
9
Assessing the Quality and Potential Efficacy of Commercial Extracts of L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory.通过分析红景天苷和红景天素含量以及海马长时程增强（一种记忆的突触模型）中的电生理活性，评估商业红景天提取物的质量和潜在功效。
Front Pharmacol. 2018 May 24;9:425. doi: 10.3389/fphar.2018.00425. eCollection 2018.
10
Preparative purification of salidroside from Rhodiola rosea by two-step adsorption chromatography on resins.通过两步树脂吸附色谱法从红景天中制备纯化红景天苷。
J Sep Sci. 2009 Jan;32(2):185-91. doi: 10.1002/jssc.200800438.
引用本文的文献
1
Applications and challenges of DNA barcoding in rapid radiation groups: (Crassulaceae) as a case study.DNA条形码在快速辐射类群中的应用与挑战：以景天科为例的研究
Chin Herb Med. 2024 Aug 8;17(3):555-561. doi: 10.1016/j.chmed.2024.08.001. eCollection 2025 Jul.
2
Salidroside inhibits melanin synthesis and melanoma growth via mTOR and PI3K/Akt pathways.红景天苷通过mTOR和PI3K/Akt信号通路抑制黑色素合成及黑色素瘤生长。
Front Oncol. 2025 Jul 10;15:1583580. doi: 10.3389/fonc.2025.1583580. eCollection 2025.
3
ACTIVA-Senior: Study Design and Protocol for a Preliminary Multidomain Outdoor Intervention Promoting Healthy Aging and Mitigating Psycho-Physiological Decline.ACTIVA-老年人：一项促进健康老龄化和减轻心理生理衰退的初步多领域户外干预研究设计与方案
Healthcare (Basel). 2025 May 10;13(10):1110. doi: 10.3390/healthcare13101110.
4
Unveiling the Potential Neuroprotective Effect of Bioactive Compounds from Plants with Sedative and Mood-Modulating Properties: Innovative Approaches for the Prevention of Alzheimer's and Parkinson's Diseases.揭示具有镇静和调节情绪特性的植物生物活性化合物的潜在神经保护作用：预防阿尔茨海默病和帕金森病的创新方法。
Curr Neuropharmacol. 2025 Feb 11. doi: 10.2174/011570159X345397241210103538.
5
Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4 signaling.红景天苷增强间充质干细胞通过Keap1/Nrf2/GPX4信号通路抑制铁死亡并改善卵巢早衰。
Redox Rep. 2025 Dec;30(1):2455914. doi: 10.1080/13510002.2025.2455914. Epub 2025 Jan 28.
6
Salidroside Prevents Keloid Fibroblast Aggressive Progression by Upregulating miR-26a-5p to Inhibit JAG1.红景天苷通过上调miR-26a-5p抑制JAG1来预防瘢痕疙瘩成纤维细胞的侵袭性进展。
Cell Biochem Biophys. 2025 Jun;83(2):2577-2587. doi: 10.1007/s12013-025-01667-9. Epub 2025 Jan 17.
7
Rosiridin prevents cisplatin-induced renal toxicity by inhibiting caspase-3/NF-κB/ Bcl-2 signaling pathways in rats and in silico study.罗西立丁通过抑制大鼠体内的半胱天冬酶-3/核因子κB/ Bcl-2信号通路预防顺铂诱导的肾毒性及计算机模拟研究。
Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398(5):5895-5913. doi: 10.1007/s00210-024-03643-1. Epub 2024 Dec 2.
8
Synthesizing network pharmacology, bioinformatics, and in vitro experimental verification to screen candidate targets of Salidroside for mitigating Alzheimer's disease.综合网络药理学、生物信息学和体外实验验证，以筛选红景天苷减轻阿尔茨海默病的候选靶点。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398(4):4539-4558. doi: 10.1007/s00210-024-03555-0. Epub 2024 Nov 6.
9
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.红景天苷通过硬脂酰辅酶A去饱和酶1（SCD1）介导的脂肪生成和核受体辅助激活因子4（NCOA4）介导的铁自噬使三阴性乳腺癌对铁死亡敏感。
J Adv Res. 2024 Sep 29. doi: 10.1016/j.jare.2024.09.027.
10
Effects of salidroside on atherosclerosis: potential contribution of gut microbiota.红景天苷对动脉粥样硬化的影响：肠道微生物群的潜在作用
Front Pharmacol. 2024 Jul 17;15:1400981. doi: 10.3389/fphar.2024.1400981. eCollection 2024.
本文引用的文献
1
Anti-Aging Implications of (Huangqi): A Well-Known Chinese Tonic.黄芪的抗衰老意义：一种著名的中国滋补品。
Aging Dis. 2017 Dec 1;8(6):868-886. doi: 10.14336/AD.2017.0816. eCollection 2017 Dec.
2
The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review.黄芩苷和黄芩素对脑缺血的影响：综述
Aging Dis. 2017 Dec 1;8(6):850-867. doi: 10.14336/AD.2017.0829. eCollection 2017 Dec.
3
Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases.银杏叶提取物对衰老相关疾病的研究进展
Aging Dis. 2017 Dec 1;8(6):812-826. doi: 10.14336/AD.2017.0615. eCollection 2017 Dec.
4
The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation.中药对神经干细胞增殖与分化的影响
Aging Dis. 2017 Dec 1;8(6):792-811. doi: 10.14336/AD.2017.0428. eCollection 2017 Dec.
5
Lycium Barbarum: A Traditional Chinese Herb and A Promising Anti-Aging Agent.枸杞：一种传统的中国草药和一种有前景的抗衰老剂。
Aging Dis. 2017 Dec 1;8(6):778-791. doi: 10.14336/AD.2017.0725. eCollection 2017 Dec.
6
Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation.黄连及小檗碱作为一种天然药物通过抗氧化和激活AMPK对抗衰老及衰老相关疾病
Aging Dis. 2017 Dec 1;8(6):760-777. doi: 10.14336/AD.2016.0620. eCollection 2017 Dec.
7
Herba Cistanches: Anti-aging.肉苁蓉：抗衰老。
Aging Dis. 2017 Dec 1;8(6):740-759. doi: 10.14336/AD.2017.0720. eCollection 2017 Dec.
8
Therapeutic Potential and Cellular Mechanisms of Panax Notoginseng on Prevention of Aging and Cell Senescence-Associated Diseases.三七在预防衰老及细胞衰老相关疾病方面的治疗潜力和细胞机制
Aging Dis. 2017 Dec 1;8(6):721-739. doi: 10.14336/AD.2017.0724. eCollection 2017 Dec.
9
Ginseng: An Nonnegligible Natural Remedy for Healthy Aging.人参：健康衰老不可忽视的天然疗法。
Aging Dis. 2017 Dec 1;8(6):708-720. doi: 10.14336/AD.2017.0707. eCollection 2017 Dec.
10
Emerging Roles of in Anti-Aging.……在抗衰老中的新作用。
（注：原文中“Emerging Roles of in Anti-Aging.”表述不完整，缺少具体所指内容，这里只能按字面意思大概翻译到这种程度。）
Aging Dis. 2017 Dec 1;8(6):691-707. doi: 10.14336/AD.2017.0410. eCollection 2017 Dec.
Zotero 插件