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利用医院出院数据预测冠状动脉搭桥手术的院内死亡率:与前瞻性观察性研究的比较

Predicting in-hospital mortality with coronary bypass surgery using hospital discharge data: comparison with a prospective observational study.

作者信息

Ribera Aida, Marsal Josep R, Ferreira-González Ignacio, Cascant Purificació, Pons Joan M V, Mitjavila Francesca, Salas Teresa, Permanyer-Miralda Gaietà

机构信息

CIBER de Epidemiología y Salud Pública, Spain.

出版信息

Rev Esp Cardiol. 2008 Aug;61(8):843-52.

Abstract

INTRODUCTION AND OBJECTIVES

The aim was to determine the usefulness of the hospital discharge Minimum Basic Data Set (MBDS) for predicting in-hospital mortality with coronary bypass surgery by using data from a prospective observational study as a reference.

METHODS

The observational study involved collecting data on all patients undergoing first coronary bypass surgery at five hospitals in Catalonia, Spain between November 2001 and November 2003. In addition, data covering the same period and hospitals were obtained from the MBDS for procedure code 36.1. We investigated the concordance between the information from the two data sources and logistic regression was used to derive predictive models for in-hospital mortality. The model derived using MBDS data was validated using data from the prospective observational study and MBDS data for the years 2004-2006. Model validity was evaluated using discrimination and calibration indices.

RESULTS

Some 4.1% of cases in the observational study could not be found in the MBDS. The concordance between the two data sources was highly variable and generally low (kappa values ranged from 0.16 to 0.79). The discriminative ability of the MBDS model was equivalent to that of the observational study model (c=0.80 vs. c=0.79), but when the validity of the former was tested using prospective data and MBDS data for 2004-2006, the discrimination c-index decreased to 0.76 and 0.65, respectively, and the calibration worsened significantly (P< .001).

CONCLUSIONS

The risk of in-hospital mortality following coronary surgery cannot be accurately evaluated using MBDS data. However, our results indicate that their use as a predictive tool could be improved.

摘要

引言与目的

目的是通过将一项前瞻性观察性研究的数据作为参考,确定医院出院最低基本数据集(MBDS)在预测冠状动脉搭桥手术住院死亡率方面的有用性。

方法

该观察性研究收集了2001年11月至2003年11月期间在西班牙加泰罗尼亚五家医院接受首次冠状动脉搭桥手术的所有患者的数据。此外,从MBDS中获取了程序代码36.1在同一时期和医院的数据。我们调查了两个数据源信息之间的一致性,并使用逻辑回归推导住院死亡率的预测模型。使用前瞻性观察性研究的数据和2004 - 2006年的MBDS数据对使用MBDS数据得出的模型进行验证。使用区分度和校准指数评估模型有效性。

结果

观察性研究中约4.1%的病例在MBDS中未找到。两个数据源之间的一致性差异很大,总体较低(kappa值范围为0.16至0.79)。MBDS模型的判别能力与观察性研究模型相当(c = 0.80对c = 0.79),但当使用前瞻性数据和2004 - 2006年的MBDS数据测试前者的有效性时,区分度c指数分别降至0.76和0.65,校准明显变差(P <.001)。

结论

使用MBDS数据无法准确评估冠状动脉手术后的住院死亡风险。然而,我们的结果表明其作为预测工具的用途可以改进。

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