Meinke David, Muralla Rosanna, Sweeney Colleen, Dickerman Allan
Department of Botany, Oklahoma State University, Stillwater, OK 74078, USA.
Trends Plant Sci. 2008 Sep;13(9):483-91. doi: 10.1016/j.tplants.2008.06.003. Epub 2008 Aug 4.
Eight years after publication of the Arabidopsis genome sequence and two years before completing the first phase of an international effort to characterize the function of every Arabidopsis gene, plant biologists remain unable to provide a definitive answer to the following basic question: what is the minimal gene set required for normal growth and development? The purpose of this review is to summarize different strategies employed to identify essential genes in Arabidopsis, an important component of the minimal gene set in plants, to present an overview of the datasets and specific genes identified to date, and to discuss the prospects for future saturation of this important class of genes. The long-term goal of this collaborative effort is to facilitate basic research in plant biology and complement ongoing research with other model organisms.
在拟南芥基因组序列公布八年后，距离完成一项旨在确定每个拟南芥基因功能的国际合作项目第一阶段还有两年时间，植物生物学家们仍然无法对以下基本问题给出明确答案：正常生长和发育所需的最小基因集是什么？本综述的目的是总结用于鉴定拟南芥中必需基因的不同策略（拟南芥是植物最小基因集的重要组成部分），概述迄今已鉴定出的数据集和特定基因，并讨论这一重要基因类别未来实现饱和的前景。这项合作努力的长期目标是促进植物生物学的基础研究，并补充正在进行的针对其他模式生物的研究。
