Liu Sheng, Cui Yong-Mei, Nan Fa-Jun
Chinese National Center for Drug Screening, State Key Laboratory of Drug Research Shanghai Institute of Materia Medica, Chinese Academy of Sciences 189 Guoshoujing Road, Zhangjiang Hi-Tech Park, Shanghai 201203,China.
Org Lett. 2008 Sep 4;10(17):3765-8. doi: 10.1021/ol801419m. Epub 2008 Aug 8.
The first total synthesis of the originally proposed and revised structure of scleritodermin A, along with an isomer, were achieved by the use of an alpha-azido carboxyl group serving as the key alpha-ketoamide precursor, thus leading to a revision of the structure originally proposed for natural scleritodermin A.
通过使用α-叠氮羧基作为关键的α-酮酰胺前体，首次实现了对最初提出的和修订后的硬皮菌素A结构以及一种异构体的全合成，从而导致了对天然硬皮菌素A最初提出的结构的修订。
