Camiciottoli Gianna, Cavigli Edoardo, Grassi Luca, Diciotti Stefano, Orlandi Ilaria, Zappa Marco, Picozzi Giulia, Pegna Andrea Lopes, Paci Eugenio, Falaschi Fabio, Mascalchi Mario
Dipartimento Area Critica, Università di Firenze, Firenze, Italy.
Eur Radiol. 2009 Jan;19(1):58-66. doi: 10.1007/s00330-008-1131-6. Epub 2008 Aug 9.
We assessed with computed tomography (CT) densitometry the prevalence of emphysema in 266 (175 men and 91 women; mean age 64 +/- 4 years) smokers and former smokers enrolled in the ITALUNG trial of lung cancer screening with low-dose thin-slice CT. Whole-lung volume and the relative area at -950 Hounsfield units (RA(950)) and mean lung attenuation (MLA) in 1 of every 10 slices (mean, 24 slices per subject) were measured. Lung volume, MLA and RA950 significantly correlated each other and with age. Average RA950 >6.8% qualifying for emphysema was present in 71 (26.6%) of 266 subjects, with a higher prevalence in men than in women (30.3% vs 19.8%; p = 0.003). Only in smokers was a weak (r = 0.18; p = 0.05) correlation between RA950 and packs/year observed. In multiple regression analysis, the variability of RA950 (R2 = 0.24) or MLA (R2 = 0.34) was significantly, but weakly explained by age, lung volume and packs/year. Other factors besides smoking may also have a significant role in the etiopathogenesis of pulmonary emphysema.
我们采用计算机断层扫描（CT）密度测定法，对参加低剂量薄层CT肺癌筛查ITALUNG试验的266名吸烟者和既往吸烟者（175名男性和91名女性；平均年龄64±4岁）的肺气肿患病率进行了评估。测量了全肺容积、每10层切片中1层的-950亨氏单位相对面积（RA(950)）和平均肺衰减（MLA）（平均每名受试者24层切片）。肺容积、MLA和RA950相互之间以及与年龄均显著相关。266名受试者中有71名（26.6%）的平均RA950>6.8%符合肺气肿诊断标准，男性患病率高于女性（30.3%对19.8%；p = 0.003）。仅在吸烟者中观察到RA950与每年吸烟包数之间存在弱相关性（r = 0.18；p = 0.05）。在多元回归分析中，RA950（R2 = 0.24）或MLA（R2 = 0.34）的变异性可被年龄、肺容积和每年吸烟包数显著但微弱地解释。除吸烟外的其他因素可能在肺气肿的发病机制中也起重要作用。
