Romani Alfredo
Laboratorio Potenziali Evocati, Istituto Neurologico C. Mondino, Via Mondino 2, 27100, Pavia, Italy.
Neurol Sci. 2008 Sep;29 Suppl 2:S247-9. doi: 10.1007/s10072-008-0952-z.
Fatigue is a psychophysiological state that acts on the subject's motivation to engage in and/or to continue strenuous physical or cognitive activities. In various pathological conditions fatigue seems to lose this homeostatic function and presents itself as a symptom. The pathophysiology of fatigue is complex and includes neurological (central and peripheral) dysfunction, and altered neurotransmitter, cytokine, and hormonal settings. Treatment interventions are generally based on a sequential approach including treatment of comorbid factors, nonpharmacological treatments, and drugs.
疲劳是一种心理生理状态，它作用于个体参与和/或持续进行剧烈体力或认知活动的动机。在各种病理状态下，疲劳似乎失去了这种稳态功能，并表现为一种症状。疲劳的病理生理学很复杂，包括神经（中枢和外周）功能障碍，以及神经递质、细胞因子和激素环境的改变。治疗干预通常基于一种循序渐进的方法，包括治疗合并因素、非药物治疗和药物治疗。
