Sugiyama Sayaka, Di Nardo Ariel A, Aizawa Shinichi, Matsuo Isao, Volovitch Michel, Prochiantz Alain, Hensch Takao K
Lab for Neuronal Circuit Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
Cell. 2008 Aug 8;134(3):508-20. doi: 10.1016/j.cell.2008.05.054.
Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical period for rewiring ocular dominance to establish visual acuity. We find that maturation of the parvalbumin (PV)-cell network that controls plasticity onset is regulated by a selective re-expression of the embryonic Otx2 homeoprotein. Visual experience promoted the accumulation of non-cell-autonomous Otx2 in PV-cells, and cortical infusion of exogenous Otx2 accelerated both PV-cell development and critical period timing. Conversely, conditional removal of Otx2 from non-PV cells or from the visual pathway abolished plasticity. Thus, the experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit.
神经回路在出生后早期由经验塑造。视觉皮层内不同的γ-氨基丁酸能连接决定了重新布线眼优势以建立视力的关键期的时间。我们发现，控制可塑性起始的小白蛋白（PV）细胞网络的成熟受胚胎Otx2同源蛋白的选择性重新表达调控。视觉经验促进了PV细胞中非细胞自主性Otx2的积累，向皮层注入外源性Otx2可加速PV细胞发育和关键期进程。相反，有条件地从非PV细胞或视觉通路中去除Otx2可消除可塑性。因此，同源蛋白的经验依赖性转移可能为神经回路的出生后可塑性建立生理环境。
