Ahmad Nooruddin, Alam Shahinul, Mustafa Golam, Adnan Abul Barkat Muhammad, Baig Rahat Hasan, Khan Mobin
Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
Hepatobiliary Pancreat Dis Int. 2008 Aug;7(4):379-82.
Bangladesh is a densely populated country where about 10 million people are chronically infected with hepatitis B virus (HBV). The aim of the present study was to evaluate the biochemical, virological and histological characteristics of HBeAg-negative chronic hepatitis B (CHB).
Patients were included in this study if they were chronically infected with HBV with detectable DNA. The patients who were co-infected with human immunodeficiency virus, hepatitis delta virus or hepatitis C virus, and previously subjected to antiviral treatment, and those with hepatocellular carcinoma were excluded. The study was conducted during the period of January 2001 to December 2007. During this period 2617 patients with CHB were studied. HBeAg-positive cases were included to compare the characteristics. Among them, 237 cases underwent liver biopsy.
2296 patients (87.7%) were male, with a mean age of 28.9+/-13.7 years. 2375 patients (90.8%) had CHB, and 242 (9.2%) were cirrhotic. HBV DNA levels were 7.6+/-1.5 copies/ml, ALT was 111.3+/-212.5 U/L, and AST was 91.5+/-148.9 U/L. The number of HBeAg-negative CHB cases was 1039 (39.7%). HBeAg-negative patients with a lower DNA load were older, and they had more fibrotic changes in the liver than HBeAg-positive patients. The two groups did not differ in necroinflammatory activity, but the former had lower ALT and AST values. Cirrhosis was more common in e-antigen-negative patients.
e-antigen-negative CHB patients are older and have more hepatic fibrosis patients than HBeAg-positive patients, although they have similar necroinflammatory activity.
孟加拉国是一个人口密集的国家，约有1000万人慢性感染乙型肝炎病毒（HBV）。本研究的目的是评估HBeAg阴性慢性乙型肝炎（CHB）的生化、病毒学和组织学特征。
如果患者慢性感染HBV且DNA可检测，则纳入本研究。排除合并感染人类免疫缺陷病毒、丁型肝炎病毒或丙型肝炎病毒的患者，以及先前接受过抗病毒治疗的患者和肝细胞癌患者。该研究于2001年1月至2007年12月期间进行。在此期间，对2617例CHB患者进行了研究。纳入HBeAg阳性病例以比较特征。其中，237例患者接受了肝活检。
2296例患者（87.7%）为男性，平均年龄28.9±13.7岁。2375例患者（90.8%）患有CHB，242例（9.2%）为肝硬化患者。HBV DNA水平为7.6±1.5拷贝/毫升，ALT为111.3±212.5 U/L，AST为91.5±148.9 U/L。HBeAg阴性CHB病例数为1039例（39.7%）。DNA载量较低的HBeAg阴性患者年龄较大，且肝脏纤维化改变比HBeAg阳性患者更多。两组在坏死性炎症活动方面无差异，但前者的ALT和AST值较低。肝硬化在e抗原阴性患者中更常见。
e抗原阴性CHB患者比HBeAg阳性患者年龄更大，肝纤维化患者更多，尽管他们的坏死性炎症活动相似。
