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氟喹诺酮类药物会提高铜绿假单胞菌中美罗培南选择的碳青霉烯类耐药性的突变频率，但使用高效药物多黏菌素B会抑制突变体的形成。

Fluoroquinolone enhances the mutation frequency for meropenem-selected carbapenem resistance in Pseudomonas aeruginosa, but use of the high-potency drug doripenem inhibits mutant formation.

作者信息

Tanimoto Koichi, Tomita Haruyoshi, Fujimoto Shuhei, Okuzumi Katsuko, Ike Yasuyoshi

机构信息

Laboratory of Bacterial Drug Resistance, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.

出版信息

Antimicrob Agents Chemother. 2008 Oct;52(10):3795-800. doi: 10.1128/AAC.00464-08. Epub 2008 Aug 11.

DOI:10.1128/AAC.00464-08
PMID:18694945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2565900/
Abstract

The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.

摘要

在亚抑菌浓度的氟喹诺酮存在的情况下，用碳青霉烯类药物筛选的铜绿假单胞菌菌株对碳青霉烯类药物的耐药突变频率会增加。这些突变体要么表现出OprD活性丧失，要么表现出mexAB-oprM表达增加。用美罗培南筛选获得的突变体分离频率最高，而多黏菌素B抑制突变体生长。

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Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina.对OXA-51的特性描述，OXA-51是在来自阿根廷的鲍曼不动杆菌无亲缘关系临床菌株中发现的一种新型D类碳青霉烯酶。
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