Tret'iakov A V, Mukhlenov A G
Vopr Onkol. 1976;22(7):65-7.
The fractionation of extracts from sarcoma 180 cells was carried out on DEAE-cellulose following the administration to tumor-bearing mice of one of chloroctyl amino-phenildioxan derivatives. The tumor regression was noted more than in 50 per cent. It was found that the tumor regression, caused by this alkylating agent, results in marked changes in the fractionation pattern of thymidilatkinases. The origin of these changes is being discussed.
在给荷瘤小鼠注射一种氯辛基氨基苯二恶烷衍生物后，对肉瘤180细胞提取物进行了DEAE - 纤维素柱层析分离。观察到肿瘤消退率超过50%。发现这种烷基化剂引起的肿瘤消退导致胸苷激酶的层析图谱发生显著变化。正在讨论这些变化的起源。
