具有修饰主链的手性肽核酸单体（PNAM）。
Chiral peptide nucleic acid monomers (PNAM) with modified backbones.
作者信息
Katritzky Alan Roy, Narindoshvili Tamari
机构信息
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
出版信息
Org Biomol Chem. 2008 Sep 7;6(17):3171-6. doi: 10.1039/b806141f. Epub 2008 Jul 9.
DOI:10.1039/b806141f
PMID:18698477
Abstract
Convenient high yielding syntheses of optically pure PNAMs comprising l- or d-serine, l-lysine and l-arginine units linked to thymine or Cbz-cytosine are described. Simple workup and inexpensive reagents are employed and free amino acids are used as coupling components.
摘要
描述了包含与胸腺嘧啶或Cbz - 胞嘧啶相连的L - 或D - 丝氨酸、L - 赖氨酸和L - 精氨酸单元的光学纯PNAM的便捷高产合成方法。采用了简单的后处理和廉价的试剂，并使用游离氨基酸作为偶联组分。
Zotero 插件