Lipscomb J A, Fenster L, Wrensch M, Shusterman D, Swan S
Special Epidemiological Studies Program, Department of Health Services, Berkeley, Calif.
J Occup Med. 1991 May;33(5):597-604.
Associations of occupational solvent exposure and/or work in electronics production with adverse pregnancy outcomes were examined in a large cross-sectional community-based reproductive health study of 1038 California women pregnant between 1980 and 1985. Occupational solvent exposure was determined by two different methods: Bureau of Census codes judged by experts to probably include solvent exposure and self-reported exposure. First trimester solvent exposure classified by either method (n = 52) was significantly associated with spontaneous abortion, adjusted odds ratio 3.34 (95% confidence interval 1.42, 7.81). Among 29 women reporting regular and daily solvent exposure, the adjusted odds ratio increased to 4.44 (95% confidence interval 1.86, 10.58). Work in electronics assembly was significantly associated with delivering a low birth weight infant (adjusted odds ratio 5.38; 95% confidence interval 1.42, 20.46) but was not associated with spontaneous abortions. Further research using biologic monitoring and/or other objective measures of exposure is needed to validate these findings.
在一项针对1980年至1985年间怀孕的1038名加利福尼亚州女性的大型基于社区的生殖健康横断面研究中，研究了职业性溶剂暴露和/或电子生产工作与不良妊娠结局之间的关联。职业性溶剂暴露通过两种不同方法确定：由专家判断可能包括溶剂暴露的人口普查代码以及自我报告的暴露情况。通过任一种方法分类的孕早期溶剂暴露（n = 52）与自然流产显著相关，校正比值比为3.34（95%置信区间1.42, 7.81）。在报告经常且每日暴露于溶剂的29名女性中，校正比值比增至4.44（95%置信区间1.86, 10.58）。从事电子装配工作与分娩低体重儿显著相关（校正比值比5.38；95%置信区间1.42, 20.46），但与自然流产无关。需要使用生物监测和/或其他客观暴露测量方法进行进一步研究以验证这些发现。
