Shusterman D, Windham G C, Fenster L
California Office of Environmental Health Hazard Assessment, Air Toxicology and Epidemiology Section, Berkeley 94704.
J Occup Med. 1993 Apr;35(4):381-6.
A large case-control study of environmental risk factors for spontaneous abortion was conducted among women living in Santa Clara County, California. Because of the prevalence of electronics production work within this population, a specialized questionnaire was administered to women who self-identified as electronics production workers. Spontaneous abortions were identified from pathology records, and controls were identified from birth certificates. The odds ratio for spontaneous abortion and any electronics production work was 0.94 (95% confidence interval = 0.58, 1.5). Odds ratios for the three main branches of electronics production (semiconductor fabrication, printed circuit board manufacturing, and assembly) were likewise near or below unity. Specific production activities with elevated odds ratios included semiconductor diffusion, parts encapsulation, soldering, and flux removal, although the numbers were small and none of the confidence intervals excluded unity. Limitations of this study included modest statistical power and a potential for nondifferential misclassification of exposures, both of which could bias findings toward the null.
在加利福尼亚州圣克拉拉县居住的女性中开展了一项关于自然流产环境危险因素的大型病例对照研究。由于该人群中从事电子产品生产工作的情况较为普遍，因此对自认为是电子产品生产工人的女性进行了一份专门问卷的调查。自然流产情况从病理记录中确定，对照则从出生证明中确定。自然流产与任何电子产品生产工作的比值比为0.94（95%置信区间=0.58，1.5）。电子产品生产的三个主要分支（半导体制造、印刷电路板制造和组装）的比值比同样接近或低于1。比值比升高的特定生产活动包括半导体扩散、零件封装、焊接和助焊剂去除，尽管数量较少且没有一个置信区间排除1。本研究的局限性包括统计效力适中以及暴露可能存在无差异错误分类，这两者都可能使研究结果偏向于无效值。
