Peyre M, Fusheng G, Desvaux S, Roger F
French Agricultural Research Center for International Development (CIRAD), AGIRs (Animal and Integrated Risk Management), Montpellier, France.
Epidemiol Infect. 2009 Jan;137(1):1-21. doi: 10.1017/S0950268808001039. Epub 2008 Aug 14.
Vaccination can be a useful tool for the control of avian influenza (AI) outbreaks, but its use is prohibited in most of the countries worldwide because of its interference with AI surveillance tests and its negative impact on poultry trade. AI vaccines currently in use in the field increase host resistance to the disease but have a limited impact on the virus transmission. To control or eradicate the disease, a carefully conceived vaccination strategy must be accompanied by strict biosecurity measures. Some countries have authorized vaccination under special circumstances with contradictory results, from control and disease eradication (Italy) to endemicity and antigenic drift of the viral strain (Mexico). Extensive vaccination programmes are ongoing in South East Asia to control the H5N1 epidemic. This review provides practical information on the available AI vaccines and associated diagnostic tests, the vaccination strategies applied in Asia and their impact on the disease epidemiology.
疫苗接种可以成为控制禽流感（AI）疫情的一项有用工具，但由于其干扰禽流感监测检测以及对家禽贸易产生负面影响，在全球大多数国家都被禁止使用。目前在实际应用中的禽流感疫苗可增强宿主对该疾病的抵抗力，但对病毒传播的影响有限。要控制或根除该疾病，精心制定的疫苗接种策略必须辅以严格的生物安全措施。一些国家已在特殊情况下批准进行疫苗接种，结果各不相同，从疫情得到控制和疾病根除（意大利）到病毒株的地方性流行和抗原漂移（墨西哥）。东南亚正在开展广泛的疫苗接种计划以控制H5N1疫情。本综述提供了有关现有禽流感疫苗及相关诊断检测、亚洲应用的疫苗接种策略及其对疾病流行病学影响的实用信息。
