Elmér M
Acta Physiol Scand. 1976 Dec;98(4):440-4. doi: 10.1111/j.1748-1716.1976.tb10333.x.
The contractile responses of the rat detrusor muscle to noradrenaline were increased 2-3 weeks after partial denervation but had returned to control values 6-9 weeks after the denervation, probably because of reinnervation of denervated muscle cells. 6-9 weeks after partial denervation the excitatory alpha-adrenoceptor mediated response to stimulation of the remaining intact nerves was predominant, masking the subsequent inhibitory beta-receptor response, which at this time was seen only after alpha-receptor blockade. The possibility of an outgrowth of adrenergic fibres activating alpha-receptors in muscle cells normally not innervated by adrenergic nerves is discussed.
部分去神经支配后2 - 3周，大鼠逼尿肌对去甲肾上腺素的收缩反应增强，但去神经支配后6 - 9周又恢复到对照值，这可能是由于失神经支配的肌细胞重新获得了神经支配。部分去神经支配后6 - 9周，由兴奋性α - 肾上腺素能受体介导的对剩余完整神经刺激的反应占主导，掩盖了随后的抑制性β - 受体反应，而此时该反应仅在α - 受体阻断后才能观察到。文中讨论了肾上腺素能纤维向通常不受肾上腺素能神经支配的肌细胞生长并激活α - 受体的可能性。
