上颌窦后鼻孔息肉中金属蛋白酶MMP - 2和MMP - 9的表达
Expression of metalloproteinases MMP-2 and MMP-9 in antrochoanal polyps.
作者信息
Topal Ozgul, Erbek Selim S, Kiyici Halil, Cakmak Ozcan
机构信息
Department of Otorhinolaryngology, Baskent University Faculty of Medicine, 06640 Bahcelievler, Ankara, Turkey.
出版信息
Am J Rhinol. 2008 Jul-Aug;22(4):339-42. doi: 10.2500/ajr.2008.22.3183.
BACKGROUND
Matrix metalloproteinase (MMP) 2 and MMP-9 are known to cleave specifically type 4 collagen, which is a major structural component of basement membrane. This is an early step of inflammation. Because of this property they have been studied in chronic sinonasal disorders. The aim of this study was to determine the MMP-2 and MMP-9 expressions in an antrochoanal polyp (ACP).
METHODS
We examined tissue samples from 10 ACPs, 10 diffuse nasal polyps, and 10 control nasal mucosa (CM) by immunohistochemistry for MMP-2 and MMP-9 expression.
RESULTS
Most of epithelial and endothelial cells showed positive immunostaining for MMP-2 and MMP-9 in all tissue samples. MMP-2 staining of inflammatory cells showed no difference among the groups (p > 0.05). On the other hand, MMP-9+ inflammatory cells were found to be significantly increased in ACP and diffuse nasal polyps when compared with CM (p < 0.05).
CONCLUSION
MMP-9-expressing inflammatory cells could play a role in the pathophysiology of ACP as well as nasal polyps.
背景
已知基质金属蛋白酶（MMP）-2和MMP-9可特异性切割Ⅳ型胶原，Ⅳ型胶原是基底膜的主要结构成分。这是炎症的早期步骤。由于这一特性，它们已在慢性鼻-鼻窦疾病中得到研究。本研究的目的是确定上颌窦后鼻孔息肉（ACP）中MMP-2和MMP-9的表达情况。
方法
我们通过免疫组织化学检测了10例ACP、10例弥漫性鼻息肉和10例对照鼻黏膜（CM）组织样本中MMP-2和MMP-9的表达。
结果
在所有组织样本中，大多数上皮细胞和内皮细胞对MMP-2和MMP-9呈阳性免疫染色。各组间炎症细胞的MMP-2染色无差异（p>0.05）。另一方面，与CM相比，ACP和弥漫性鼻息肉中MMP-9+炎症细胞显著增加（p<0.05）。
结论
表达MMP-9的炎症细胞可能在ACP以及鼻息肉的病理生理学中发挥作用。
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