Wachleski Cláudia, Salum Giovanni Abrahão, Blaya Carolina, Kipper Letícia, Paludo Angela, Salgado Ana Paula, Manfro Gisele Gus
Anxiety Disorder Program, Hospital de Clínicas de Porto Alegre and Graduate Program in Medical Sciences, Psychiatry, Universidade Federal do Rio Grande do Sul, Brazil.
Compr Psychiatry. 2008 Sep-Oct;49(5):476-81. doi: 10.1016/j.comppsych.2008.03.003. Epub 2008 Jun 3.
The purpose of the study is to compare the personality traits assessed with the Temperament and Character Inventory (TCI) between patients with panic disorder (PD) and a control group in a Brazilian sample.
One hundred thirty-five patients with PD paired according to sex and age with 135 controls without any psychiatric disorders were assessed with the Mini International Neuropsychiatric Interview (MINI), a structured interview. Temperament and character were assessed with the TCI.
Consistently, patients with PD presented higher scores on the harm avoidance (HA) temperament scale (23.20 +/- 5.41 vs 15.21 +/- 4.92; P < .001) and lower scores on the self-directedness (SD) (27.81 +/- 7.25 vs 35.16 +/- 5.47; P < .001) if compared to the control group and has been associated independently from other TCI scales and confounders with PD. The multivariate logistic model containing HA and SD explains 38.6% to 51.4% of the differences between PD and controls.
Harm avoidance could be a good candidate to be heritable because it appears to be a consistent finding across current literature in anxious and depressed patients independent of their cultural context. Also, SD seems to be a key character characteristic of PD patients. The dimensional assessment is an interesting alternative for understanding the relationship between the psychobiologic bases of temperament and character and is highly related to the development of psychiatric syndromes.
本研究旨在比较巴西样本中惊恐障碍（PD）患者与对照组使用气质与性格问卷（TCI）评估的人格特质。
135例PD患者按性别和年龄与135名无任何精神障碍的对照者配对，使用结构化访谈工具迷你国际神经精神访谈（MINI）进行评估。用TCI评估气质和性格。
与对照组相比，PD患者在回避伤害（HA）气质量表上的得分始终较高（23.20±5.41对15.21±4.92；P<.001），而在自我导向（SD）量表上的得分较低（27.81±7.25对35.16±5.47；P<.001），且与其他TCI量表及混杂因素无关，独立与PD相关。包含HA和SD的多变量逻辑模型解释了PD组与对照组之间38.6%至51.4%的差异。
回避伤害可能是一个良好的遗传候选因素，因为在当前关于焦虑和抑郁患者的文献中，无论文化背景如何，这似乎都是一个一致的发现。此外，SD似乎是PD患者的一个关键性格特征。维度评估是理解气质和性格的心理生物学基础之间关系的一个有趣的选择，并且与精神综合征的发展高度相关。
