Malabu U H, Founda M A
Department of Medicine, King Khalid University Hospital, P.O.BOX 7805, Riyadh 11472, Saudi Arabia.
Med J Malaysia. 2007 Dec;62(5):394-7.
Records of 46 patients who were treated for primary hyperparathyroidism at King Khalid University Hospital, Riyadh Saudi Arabia from 1st July 2000 to 30th June 2006 were reviewed. Mean age at diagnosis was 44 years (range 13-70 years) and average duration of symptoms was 39 months (1 month to 11 years). There were 35 females and 11 males with a ratio of 3.2:1. Bone pains were the major symptoms at presentation in 45.7% followed by no symptom in 23.9%, renal stones in 15.2%, polyuria in 6.5%, while 4.3% each presented with depression, and constipation. Males had significantly more severe disease with higher serum calcium, higher urinary calcium excretion, and higher serum creatinine. Ninety six percent of patients had successful surgery and 4% (two patients) each had recurrence and hungry bone syndrome. It is concluded that PHPT in Saudi Arabia continues to be a symptomatic disorder with skeletal and renal manifestations occurring at a younger age and males having more severe disease. Further prospective studies are needed to verify our findings.
回顾了2000年7月1日至2006年6月30日在沙特阿拉伯利雅得的哈立德国王大学医院接受原发性甲状旁腺功能亢进治疗的46例患者的记录。诊断时的平均年龄为44岁（范围13 - 70岁），症状的平均持续时间为39个月（1个月至11年）。有35名女性和11名男性，比例为3.2:1。骨痛是45.7%患者就诊时的主要症状，其次是23.9%的患者无症状，15.2%的患者有肾结石，6.5%的患者有多尿，而各有4.3%的患者表现为抑郁和便秘。男性的病情明显更严重，血清钙更高、尿钙排泄更高、血清肌酐更高。96%的患者手术成功，4%（两名患者）分别出现复发和饥饿骨综合征。结论是，沙特阿拉伯的原发性甲状旁腺功能亢进仍然是一种有症状的疾病，骨骼和肾脏表现出现在较年轻的年龄，男性病情更严重。需要进一步的前瞻性研究来验证我们的发现。
