2006年至2007年台湾肠道病毒71型B5和C5亚基因型的流行情况。
The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from 2006 to 2007.
作者信息
Huang Yuan-Pin, Lin Tsuey-Li, Kuo Chuan-Yi, Lin Miao-Wen, Yao Ching-Yuan, Liao Hui-Wen, Hsu Li-Ching, Yang Chen-Fu, Yang Jyh-Yuan, Chen Pei-Jer, Wu Ho-Sheng
机构信息
Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan.
出版信息
Virus Res. 2008 Nov;137(2):206-12. doi: 10.1016/j.virusres.2008.07.015. Epub 2008 Sep 6.
Enteroviruses (EVs) are among the most common pathogens in humans. EV71 infections have caused devastating enterovirus-associated outcomes in children globally. In this study, eleven EV71 isolates in Taiwan during 2006-2007 were selected for N-terminal VP1 gene analysis. A fragment of 403 bp on VP1 gene was sequenced and a phylogenetic analysis was performed. In addition, the full-length genome sequencing was carried out on two selected isolates. The results showed that subgenogroups of B5 and C5 had circulated and become predominant in Taiwan over the specified 2 years. Moreover, glutamic acid and threonine are found conservative at positions 43 and 58 on VP1 for genogroup B; however they are replaced by lysine and alanine, respectively, for genogroup C. To our knowledge, this is the first report describing the circulation of these two EV71 subgenogroups in Taiwan.
肠道病毒（EVs）是人类最常见的病原体之一。EV71感染在全球范围内给儿童带来了与肠道病毒相关的灾难性后果。在本研究中，选取了2006 - 2007年台湾的11株EV71分离株进行VP1基因N端分析。对VP1基因上一段403 bp的片段进行测序并进行系统发育分析。此外，对两个选定的分离株进行了全长基因组测序。结果表明，在特定的两年间，B5和C5亚基因组在台湾地区传播并成为优势毒株。此外，发现B基因组VP1蛋白第43位和58位的谷氨酸和苏氨酸是保守的；然而，对于C基因组，它们分别被赖氨酸和丙氨酸取代。据我们所知，这是首次描述这两个EV71亚基因组在台湾地区传播情况的报告。
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