Pek Y S, Gao Shujun, Arshad M S Mohamed, Leck Kwong-Joo, Ying Jackie Y
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos #04-01, Singapore 138669, Singapore.
Biomaterials. 2008 Nov;29(32):4300-5. doi: 10.1016/j.biomaterials.2008.07.030. Epub 2008 Aug 15.
We have created a porous bioresorbable nanocomposite bone scaffold that chemically, structurally and mechanically matched natural bone so that it could be recognized and remodeled by natural bone. Containing collagen fibers and synthetic apatite nanocrystals, our scaffold has high strength for supporting the surrounding tissue. The foam-like scaffold has a similar microstructure as trabecular bone, with nanometer-sized and micron-sized pores. The apatitic phase of the scaffold exhibited similar chemical composition, crystalline phase and grain size as the trabecular bone apatite. The nanocomposite scaffold demonstrated excellent bioactivity for promoting cell attachment and proliferation. It was osteoconductive and successfully healed a non-union fracture in rat femur as well as a critical-sized defect in pig tibia.
我们制备了一种多孔可生物降解纳米复合骨支架，其在化学、结构和力学性能上与天然骨相匹配，从而能够被天然骨识别并进行重塑。我们的支架含有胶原纤维和合成磷灰石纳米晶体，具有高强度以支撑周围组织。这种泡沫状支架具有与松质骨相似的微观结构，有纳米级和微米级的孔隙。支架的磷灰石相在化学成分、晶相和晶粒尺寸方面与松质骨磷灰石相似。这种纳米复合支架在促进细胞附着和增殖方面表现出优异的生物活性。它具有骨传导性，成功治愈了大鼠股骨的骨不连骨折以及猪胫骨的临界尺寸缺损。
