单胺氧化酶A基因型不会调节成年人的静息脑代谢。
The MAO-A genotype does not modulate resting brain metabolism in adults.
作者信息
Alia-Klein Nelly, Kriplani Aarti, Pradhan Kith, Ma Jim Yeming, Logan Jean, Williams Benjamin, Craig Ian W, Telang Frank, Tomasi Dardo, Goldstein Rita Z, Wang Gene-Jack, Volkow Nora D, Fowler Joanna S
机构信息
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States.
出版信息
Psychiatry Res. 2008 Oct 30;164(1):73-6. doi: 10.1016/j.pscychresns.2007.12.010. Epub 2008 Aug 15.
Abstract
Variation in the monoamine-oxidase-A (MAO-A) gene has been associated with volumetric changes in corticolimbic regions with differences in their response to relevant emotional tasks. Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype.
摘要
单胺氧化酶A（MAO-A）基因的变异与皮质边缘区域的体积变化有关，这些区域对相关情感任务的反应存在差异。在这里，我们发现，作为基因型的一个函数，基线区域脑代谢没有变化，这表明在没有刺激的情况下，皮质边缘活动不受MAO-A基因型的调节。
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