Geisler W M, Black C M, Bandea C I, Morrison S G
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-0007, USA.
Sex Transm Infect. 2008 Dec;84(7):541-4; discussion 544-5. doi: 10.1136/sti.2008.030825. Epub 2008 Aug 15.
To investigate the relationship of Chlamydia trachomatis (CT) outer membrane protein A (OmpA) type to the clearance of CT infection before treatment.
CT OmpA genotyping, with amplification and sequencing of ompA, was utilised to study the natural history of CT infection (spontaneous resolution vs persistence) in 102 individuals with chlamydia-positive screening tests returning for treatment.
CT OmpA distribution was associated with spontaneous resolution of CT, most notably with CT OmpA genotype J/Ja detected more often from the initial screening CT test than other genotypes in those who then had spontaneous resolution of CT noted at the time of treatment. Five individuals with presumed persisting CT infection had discordant CT OmpA genotypes at the screening and treatment visits, suggesting possible new interval CT infection.
Clearance of chlamydia by the host before treatment may be influenced by the CT OmpA genotype infecting the host. CT OmpA genotyping may be a valuable tool in understanding the natural history of chlamydial infections.
研究沙眼衣原体（CT）外膜蛋白A（OmpA）类型与治疗前CT感染清除情况的关系。
采用ompA扩增和测序的CT OmpA基因分型方法，研究102例衣原体筛查阳性且回来接受治疗的个体中CT感染的自然病程（自发清除与持续感染）。
CT OmpA分布与CT的自发清除相关，最显著的是在那些治疗时CT自发清除的个体中，与其他基因型相比，初始筛查CT检测中更常检测到CT OmpA基因型J/Ja。5例推测为持续CT感染的个体在筛查和治疗就诊时CT OmpA基因型不一致，提示可能有新的期间CT感染。
宿主在治疗前清除衣原体可能受感染宿主的CT OmpA基因型影响。CT OmpA基因分型可能是了解衣原体感染自然病程的有价值工具。
