与艾滋病病毒相关的肺部疾病
HIV-Related Lung Disorders.
作者信息
Twigg Homer L, Knox Kenneth S
机构信息
Division of Pulmonary and Critical Care Medicine, Indiana University Medical Center, Indianapolis, Indiana.
出版信息
Drug Discov Today Dis Mech. 2007;4(2):95-101. doi: 10.1016/j.ddmec.2007.11.001.
Abstract
Highly active antiretroviral therapy (HAART) has dramatically altered the spectrum of morbidity and mortality in HIV-infected patients. This has been attributed to improvements in the lung microenvironment leading to enhanced pulmonary immunity, either by preventing the progressive loss of immune function or by actually promoting immune restoration. However, these changes have been accompanied by the recognition of new pulmonary complications in HIV-infected subjects, especially those associated with immune reconstitution. In this review we will describe how HIV infection alters the normal pulmonary environment, highlight the effect of HAART on these perturbations, and discuss potential complications of HAART in the lung, focusing on the pulmonary immune reconstitution inflammatory syndrome.
摘要
高效抗逆转录病毒疗法（HAART）极大地改变了HIV感染患者的发病和死亡谱。这归因于肺微环境的改善，通过防止免疫功能的逐步丧失或实际促进免疫恢复，从而增强了肺部免疫力。然而，这些变化伴随着在HIV感染受试者中发现新的肺部并发症，尤其是那些与免疫重建相关的并发症。在本综述中，我们将描述HIV感染如何改变正常的肺部环境，强调HAART对这些紊乱的影响，并讨论HAART在肺部的潜在并发症，重点是肺部免疫重建炎症综合征。
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