HIV感染者的呼吸道微生物群
The respiratory microbiome of HIV-infected individuals.
作者信息
Lawani M B, Morris A
机构信息
a University of Pittsburgh , School of Medicine, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine , Pittsburgh , PA , USA.
出版信息
Expert Rev Anti Infect Ther. 2016 Aug;14(8):719-29. doi: 10.1080/14787210.2016.1206469.
Abstract
INTRODUCTION
The respiratory tract is constantly exposed to various environmental and endogenous microbes; however, unlike other similar mucosal surfaces, there has been limited investigation of the microbiome of the respiratory tract.
AREAS COVERED
In this review, we summarize the current state of knowledge of the bacterial, fungal, and viral respiratory microbiomes during HIV infection and how the microbiome might relate to HIV-associated lung disease. Expert commentary: HIV infection is associated with alterations in the respiratory microbiome. The clinical implications of lung microbial dysbiosis are however currently unknown. Mechanistic studies are needed to establish causality between shifts in the respiratory microbiome and pulmonary complications in HIV-infected individuals.
摘要
引言
呼吸道持续暴露于各种环境和内源性微生物中；然而，与其他类似的粘膜表面不同，对呼吸道微生物群的研究有限。
涵盖领域
在本综述中，我们总结了HIV感染期间细菌、真菌和病毒呼吸道微生物群的当前知识状态，以及微生物群与HIV相关肺部疾病的关系。专家评论：HIV感染与呼吸道微生物群的改变有关。然而，肺部微生物群失调的临床意义目前尚不清楚。需要进行机制研究以确定HIV感染者呼吸道微生物群变化与肺部并发症之间的因果关系。
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