Matusiak Lukasz, Bieniek Andrzej, Wozniak Zdzislaw, Szepietowski Jacek Cezary
Department of Dermatology, Venereology and Allergology, Medical University, Chalubinskiego 1, 50-368 Wroclaw, Poland.
Acta Dermatovenerol Alp Pannonica Adriat. 2008 Jun;17(2):72-4.
We present the case of a 74-year-old white female admitted to the Department of Dermatology because of a tumor in the IV-V interdigital area of her right foot. A crimson, dome-shaped tumor with a granular, spongy surface (diameter 4 cm) had developed over a period of about 3 months. The biopsy, stained with H and E, revealed an anaplastic malignant tumor. Additional immunochemical staining with Melan A allowed us to make the final diagnosis: amelanotic malignant melanoma (MM). The melanoma was removed by amputation of digits IV and V, with partial removal of the metatarsal bones (Clark degree 5, Breslow thickness 9 mm). Sentinel node biopsy was done using Tc99; it revealed no neoplastic alteration. The patient is still under oncological observation.
我们报告一例74岁白人女性因右脚IV - V趾间区域出现肿瘤而入住皮肤科的病例。一个深红色、圆顶状、表面呈颗粒状且质地海绵样的肿瘤（直径4厘米）在大约3个月的时间里逐渐形成。经苏木精和伊红（H&E）染色的活检显示为间变性恶性肿瘤。通过Melan A进行的额外免疫化学染色使我们能够做出最终诊断：无色素性恶性黑色素瘤（MM）。通过切除IV和V趾以及部分跖骨（Clark分级5级，Breslow厚度9毫米）将黑色素瘤切除。使用Tc99进行前哨淋巴结活检；结果显示无肿瘤性改变。该患者仍在接受肿瘤学观察。
