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Efficient ytterbium triflate catalyzed microwave-assisted synthesis of 3-acylacrylic acid building blocks.

作者信息

Tolstoluzhsky Nikita V, Gorobets Nikolay Yu, Kolos Nadezhda N, Desenko Sergey M

机构信息

Department of Organic Chemistry, V. N. Karazin Kharkiv National University, Svobody Square, 4, Kharkiv 61077, Ukraine.

出版信息

J Comb Chem. 2008 Nov-Dec;10(6):893-6. doi: 10.1021/cc800103f. Epub 2008 Aug 21.

DOI:10.1021/cc800103f
PMID:18715040
Abstract

The derivatives of 4-(hetero)aryl-4-oxobut-2-enoic acid are useful as building blocks in the synthesis of biologically active compounds. An efficient general protocol for the synthesis of these building blocks was developed. This method combines microwave assistance and ytterbium triflate catalyst and allows the fast preparation of the target acids starting from different (hetero)aromatic ketones and glyoxylic acid monohydrate giving pure products in 52-75% isolated yields.

摘要

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