由热带利什曼原虫引起的阿尔及利亚皮肤利什曼病。
Cutaneous leishmaniasis caused by Leishmania tropica in Algeria.
作者信息
Mihoubi Ilhem, Picot Stéphane, Hafirassou Nadia, de Monbrison Frédérique
机构信息
Laboratoire de Biosynthèse et Ecologie des Arthropodes, Faculté des Sciences de la Nature et de la Vie, Université Mentouri, Constantine, Algérie.
出版信息
Trans R Soc Trop Med Hyg. 2008 Nov;102(11):1157-9. doi: 10.1016/j.trstmh.2008.06.013. Epub 2008 Aug 20.
Cutaneous leishmaniasis is endemic in Algeria, but clinical and parasitological data from this area are scarce. In order to document the transmission of this disease in a peri-urban setting, cutaneous lesions from patients living in Constantine City and surrounding areas were spotted on filter paper for diagnosis and species identification using real-time PCR. Surprisingly, Leishmania tropica was detected in 6/69 patients, and confirmation was obtained by sequencing. This observation suggests a modification of the epidemiology of cutaneous leishmaniasis in Algeria and should alert physicians and policy-makers to the risk of antimony treatment failure with this species.
皮肤利什曼病在阿尔及利亚呈地方性流行，但该地区的临床和寄生虫学数据匮乏。为了记录这种疾病在城市周边地区的传播情况，居住在君士坦丁市及其周边地区的患者的皮肤病变被点样在滤纸上，以便使用实时聚合酶链反应进行诊断和物种鉴定。令人惊讶的是，在69名患者中有6名检测到热带利什曼原虫，通过测序得到了确认。这一观察结果表明阿尔及利亚皮肤利什曼病的流行病学有所改变，应提醒医生和政策制定者注意该物种导致锑治疗失败的风险。
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