Florendo K N, Bellflower B, van Zwol A, Cooke R J
Division of Neonatology, University of Tennessee Center for Health Sciences, Memphis, TN, USA.
J Perinatol. 2009 Feb;29(2):106-11. doi: 10.1038/jp.2008.124. Epub 2008 Aug 21.
To compare feeding tolerance, nutrient intake and growth in preterm infants (< or =32 weeks, < or =1750 g) fed either a standard nonhydrolyzed whey-casein (nHWC) or a partially hydrolyzed whey (pHW) preterm infant formula.
In this double-blind randomized controlled trial infants were fed either formula for at least 3 weeks. Intake was monitored daily, serum chemistries and growth weekly. Data were analyzed using analysis of covariance.
A total of 80 infants were enrolled, 72 completed the study. No differences were noted in demographic characteristics. No differences were detected in feeding tolerance, intakes (118+/-21 vs 119+/-14; nHWC vs pHW) or growth weight, 28+/-1.5 vs 28+/-1.6 g per day; length, 1.0+/-0.7 vs 1.0+/-0.6 cm per week; head circumference, 0.9+/-0.4 vs 1.0+/-0.44 cm per week). At the end of study, blood urea nitrogen (5.2+/-3.1 <6.7+/-2.3 mg per 100 ml, nHWC<pHW), total serum proteins (4.7+/-0.4 >4.4+/-0.5 g per 100 ml) and albumin (2.7+/-0.3 >2.6+/-0.4 g per 100 ml) differed.
A pHW preterm infant formula was not associated with improved feeding tolerance, enteral intake or growth but differences in serum chemistries. These are unlikely to be clinically relevant because values were well within normal limits for preterm infants, whereas growth was identical in both groups and paralleled that 'in utero'.
比较用标准非水解乳清 - 酪蛋白(nHWC)或部分水解乳清(pHW)早产儿配方奶喂养的早产儿(孕周≤32周,出生体重≤1750克)的喂养耐受性、营养摄入及生长情况。
在这项双盲随机对照试验中,婴儿用其中一种配方奶喂养至少3周。每天监测摄入量,每周监测血清化学指标和生长情况。采用协方差分析对数据进行分析。
共纳入80名婴儿,72名完成研究。两组在人口统计学特征上无差异。在喂养耐受性、摄入量(118±21与119±14;nHWC与pHW)或生长方面(体重,每天28±1.5与28±1.6克;身长,每周1.0±0.7与1.0±0.6厘米;头围,每周0.9±0.4与1.0±0.44厘米)未检测到差异。研究结束时,血尿素氮(5.2±3.1<6.7±2.3毫克/100毫升,nHWC<pHW)、总血清蛋白(4.7±0.4>4.4±0.5克/100毫升)和白蛋白(2.7±0.3>2.6±0.4克/100毫升)存在差异。
pHW早产儿配方奶与改善喂养耐受性、肠内摄入量或生长无关,但血清化学指标存在差异。这些差异不太可能具有临床相关性,因为各项指标值均在早产儿正常范围内,而且两组生长情况相同,与“宫内”生长情况相似。