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呼肠孤病毒1型和3型在肠道上皮细胞的顶端表面结合并内化。

Reovirus 1 and 3 bind and internalise at the apical surface of intestinal epithelial cells.

作者信息

Ambler L, Mackay M

机构信息

Research and Preclinical Development, CIBA-GEIGY Pharmaceuticals, Horsham, United Kingdom.

出版信息

Virology. 1991 Sep;184(1):162-9. doi: 10.1016/0042-6822(91)90832-v.

DOI:10.1016/0042-6822(91)90832-v
PMID:1871963
Abstract

Displacement of [125I]reovirus from the surface of L cells by homologous and heterologous reovirus serotypes has indicated the presence of two different receptors. Corresponding experiments with Caco-2 cells and apical membrane vesicles suggest either two different receptors or different affinity of each reovirus serotype for the same receptor. Binding and internalisation of reovirus at the apical surface of Caco-2 cells and apical membrane vesicles has been demonstrated and the implications of this for models of reovirus infectivity in the intestine are discussed.

摘要

同源和异源呼肠孤病毒血清型将[125I]呼肠孤病毒从L细胞表面置换，这表明存在两种不同的受体。对Caco-2细胞和顶端膜囊泡进行的相应实验表明，要么存在两种不同的受体，要么每种呼肠孤病毒血清型对同一受体具有不同的亲和力。已经证实呼肠孤病毒在Caco-2细胞顶端表面和顶端膜囊泡处的结合与内化，并讨论了其对肠道中呼肠孤病毒感染性模型的影响。

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Reovirus 1 and 3 bind and internalise at the apical surface of intestinal epithelial cells.呼肠孤病毒1型和3型在肠道上皮细胞的顶端表面结合并内化。
Virology. 1991 Sep;184(1):162-9. doi: 10.1016/0042-6822(91)90832-v.
2
Binding of 125I-labeled reovirus to cell surface receptors.125I标记的呼肠孤病毒与细胞表面受体的结合
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Reovirus type 1 and type 3 differ in their binding to isolated intestinal epithelial cells.1型呼肠孤病毒和3型呼肠孤病毒在与分离出的肠上皮细胞结合方面存在差异。
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