Wolf R E, Ziff M
Arthritis Rheum. 1976 Nov-Dec;19(6):1271-7. doi: 10.1002/art.1780190607.
The cell-mediated immune response of lymphocytes to rubella, measles, parainfluenza types 1, 2, and 3, varicella-zoster and herpes virus type 1 virus antigens was evaluated in 15 SLE patients and 15 matched controls by incorporating 3H-thymidine in whole blood cultures as a measure of blastic transformation. SLE patients were less responsive than normal individuals to six of eight virus antigens tested. Culture of washed SLE cells in AB plasma did not reverse the hyporesponsiveness. The results indicated that a functional impairment of the circulating lymphocytes appeared to be responsible for the in vitro hyporesponsiveness of SLE patients to virus antigens.
通过在全血培养物中加入³H-胸腺嘧啶核苷作为母细胞转化的指标，对15例系统性红斑狼疮（SLE）患者和15例配对对照者淋巴细胞对风疹、麻疹、1型、2型和3型副流感病毒、水痘-带状疱疹病毒及1型疱疹病毒抗原的细胞介导免疫反应进行了评估。SLE患者对所检测的8种病毒抗原中的6种反应比正常个体弱。在AB血浆中培养洗涤过的SLE细胞并不能逆转这种低反应性。结果表明，循环淋巴细胞的功能损害似乎是SLE患者体外对病毒抗原低反应性的原因。
