Pincus T, Steinberg A D, Blacklow N R, Decker J L
Arthritis Rheum. 1978 Nov-Dec;21(8):873-9. doi: 10.1002/art.1780210801.
Sera of patients with systemic lupus erythematosus (SLE) showed significantly higher complement fixation reactivities with 8 of 10 virus antigen preparations compared to sera of normal subjects, including virus workers, confirming earlier observations. However, one-third of SLE sera were also reactive with cellular antigens, prepared in a manner identical to viral antigens, but from cells not infected with virus. By contrast, only one of 49 normal sera showed reactivity with one of nine cellular antigens, at a minimal titer. Apparently heightened reactivities of SLE sera with virus antigens could be explained in many instances on the basis of reactions with cellular antigens. Serum reactivities with nonviral tissue antigens in SLE must be considered in interpretation of immunologic studies related to viruses and SLE.
与正常受试者（包括病毒工作者）的血清相比，系统性红斑狼疮（SLE）患者的血清与10种病毒抗原制剂中的8种显示出明显更高的补体结合反应性，证实了早期的观察结果。然而，三分之一的SLE血清也与细胞抗原发生反应，这些细胞抗原的制备方式与病毒抗原相同，但来自未感染病毒的细胞。相比之下，49份正常血清中只有1份与9种细胞抗原中的1种在最低滴度下显示出反应性。在许多情况下，SLE血清与病毒抗原明显增强的反应性可以基于与细胞抗原的反应来解释。在解释与病毒和SLE相关的免疫学研究时，必须考虑SLE血清与非病毒组织抗原的反应性。
