el-Kady A A, Mansy M M, Nagib H S, Kessel E
Department of Obstetrics and Gynecology, Boulak El-Dakrour Hospital, Giza, Egypt.
Adv Contracept. 1991 Mar;7(1):1-9. doi: 10.1007/BF01850712.
To study the sequence of histopathologic changes taking place in the cornual portion of the fallopian tube subsequent to exposure to quinacrine, 252 mg were inserted transcervically in 12 women awaiting hysterectomy for non-malignant conditions of the uterus. All patients who underwent surgery within ten days of insertion were found to have necrosis of the epithelial lining and an acute inflammatory reaction. Later on, the changes observed included progressive absorption of the inflammatory cellular exudate, progressive fibrosis, with partial or almost complete occlusion of the lumen, and failure of regeneration of the epithelial lining. Our results support other studies indicating that quinacrine can effectively produce tubal fibrosis and occlusion.
为研究输卵管子宫角部在接触奎纳克林后发生的组织病理学变化序列，对12名因子宫非恶性疾病等待子宫切除术的女性经宫颈插入252毫克奎纳克林。所有在插入后十天内接受手术的患者均发现上皮衬里坏死和急性炎症反应。后来观察到的变化包括炎性细胞渗出物逐渐吸收、逐渐纤维化，管腔部分或几乎完全闭塞，以及上皮衬里再生失败。我们的结果支持其他研究，表明奎纳克林可有效导致输卵管纤维化和闭塞。
