沃纳综合征RecQ解旋酶在DNA复制中的作用。
Roles of the Werner syndrome RecQ helicase in DNA replication.
作者信息
Sidorova Julia M
机构信息
Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA.
出版信息
DNA Repair (Amst). 2008 Nov 1;7(11):1776-86. doi: 10.1016/j.dnarep.2008.07.017. Epub 2008 Sep 6.
Abstract
Congenital deficiency in the WRN protein, a member of the human RecQ helicase family, gives rise to Werner syndrome, a genetic instability and cancer predisposition disorder with features of premature aging. Cellular roles of WRN are not fully elucidated. WRN has been implicated in telomere maintenance, homologous recombination, DNA repair, and other processes. Here I review the available data that directly address the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. I further discuss this role of WRN within the contexts of damage tolerance group of regulatory pathways, and redundancy and cooperation with other RecQ helicases.
摘要
WRN蛋白是人类RecQ解旋酶家族的成员之一，先天性缺乏该蛋白会导致沃纳综合征，这是一种具有早衰特征的遗传不稳定和癌症易感性疾病。WRN的细胞功能尚未完全阐明。WRN与端粒维持、同源重组、DNA修复及其他过程有关。在此，我回顾了直接探讨WRN在复制过程中维持DNA完整性作用的现有数据，并提出WRN可在协调复制叉进展与复制应激诱导的叉重塑中发挥作用。我还在损伤耐受调节途径组的背景下进一步讨论了WRN的这一作用，以及它与其他RecQ解旋酶的冗余性和协同作用。
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