Makhija Divya, Mathai Alka Mary, Naik Ramadas, Kumar Suneet, Rai Sharada, Pai Muktha R, Baliga Poornima
Department of Pathology, Kasturba Medical College, Mangalore, Karnataka, India.
Indian J Pathol Microbiol. 2008 Jul-Sep;51(3):346-50. doi: 10.4103/0377-4929.42508.
Five hundred endometrial specimens were studied to document the changes in blood vessels in various phases of menstrual cycle, menstrual disturbances and in unexplained infertility. Sixty-three cases were taken as control and 437 cases as study group which included cases of dysfunctional uterine bleeding (DUB), endometrial polyps, fibroids, adenomyosis, infertility and atrophic endometrium. Using light microscopy, the vascular morphology was studied. The blood vessels were concentrated more in basal layer in the proliferative phase and in functional layer in the secretory phase. Cases of complex hyperplasia and pill endometrium had significantly higher vessel concentration. Congestion and dilatation of blood vessels were significantly higher in cases of DUB. The present study showed a positive correlation between endometrial angiogenesis and menstrual disorders. The alteration in blood vessel morphology has significant role in prognosis and in various anti-angiogenic therapies.
对500份子宫内膜标本进行研究，以记录月经周期各阶段、月经紊乱及不明原因不孕症中血管的变化。63例作为对照组，437例作为研究组，研究组包括功能失调性子宫出血（DUB）、子宫内膜息肉、子宫肌瘤、子宫腺肌病、不孕症及萎缩性子宫内膜病例。采用光学显微镜研究血管形态。增殖期血管更多集中在基底层，分泌期则集中在功能层。复杂性增生和息肉样子宫内膜病例的血管密度显著更高。DUB病例中血管充血和扩张明显更严重。本研究表明子宫内膜血管生成与月经紊乱之间存在正相关。血管形态的改变在预后及各种抗血管生成治疗中具有重要作用。
