Itha Muni Bhavani, Katta Ramya, Grace Golla Reethi S, Chinam Aparna, Nageswara Rao Kakumanu
Pathology, Guntur Medical College, Guntur, IND.
Cureus. 2024 Sep 27;16(9):e70303. doi: 10.7759/cureus.70303. eCollection 2024 Sep.
Background Abnormal uterine bleeding (AUB) is one of the most common problems encountered in gynaecological practice. Defective endometrial angiogenesis has been implicated in various benign and malignant disorders of the endometrium. Aim This study aims to assess morphometry of endometrial glands and blood vessels in patients with AUB. Material and methods This is a one year retrospective cross sectional analysis of endometrial samples received with the diagnosis of AUB in reproductive age group. All samples were routinely processed and stained. Sections were analysed for morphometry of blood vessels and endometrial glands. Results A total of 374 cases were included. Most common histological group was proliferative followed by secretory phase. A significant difference was noted in mean vascular density, diameter, mitotic scores and height of glandular epithelium in different benign and malignant groups. Conclusion This study highlights the fact that glandular and vascular morphometry can be used to differentiate between various proliferative disorders of the endometrium. In the current era of new anti-angiogenic therapies, endometrial angiogenesis and changes in vascular morphology can be targeted, thus improving treatment modalities and patient care.
背景 异常子宫出血（AUB）是妇科实践中最常见的问题之一。子宫内膜血管生成缺陷与子宫内膜的各种良性和恶性疾病有关。目的 本研究旨在评估AUB患者子宫内膜腺体和血管的形态测量学。材料与方法 这是一项对育龄期诊断为AUB的子宫内膜样本进行的为期一年的回顾性横断面分析。所有样本均常规处理和染色。对切片进行血管和子宫内膜腺体的形态测量学分析。结果 共纳入374例病例。最常见的组织学类型是增殖期，其次是分泌期。在不同的良性和恶性组中，平均血管密度、直径、有丝分裂评分和腺上皮高度存在显著差异。结论 本研究强调了这样一个事实，即腺体和血管形态测量学可用于区分子宫内膜的各种增殖性疾病。在当前新的抗血管生成治疗时代，可以针对子宫内膜血管生成和血管形态变化，从而改善治疗方式和患者护理。
