Burgess Helen J, Fogg Louis F
Biological Rhythms Research Laboratory, Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.
PLoS One. 2008 Aug 26;3(8):e3055. doi: 10.1371/journal.pone.0003055.
The aim of this study was to examine individual differences in a large sample of complete melatonin profiles not suppressed by light and search for possible associations between the amount and timing of melatonin secretion and a multitude of lifestyle variables. The melatonin profiles were derived from saliva samples collected every 30 minutes in dim light from 85 healthy women and 85 healthy men aged 18-45 years. There was a large individual variability in the amount of melatonin secreted with peak values ranging from 2 to 84 pg/ml. The onset of melatonin secretion ranged from 18:13 to 00:26 hours. The use of hormonal birth control, reduced levels of employment, a smaller number of days on a fixed sleep schedule, increased day length and lower weight were associated with an increased amplitude of melatonin secretion. The use of hormonal birth control, contact lenses, a younger age, and lower ratings of mania and paranoia were associated with a longer duration of melatonin secretion. An earlier occurrence of the onset of melatonin secretion was associated with an earlier wake time, more morningness and the absence of a bed partner. Lifestyle and behavioral variables were only able to explain about 15% of the individual variability in the amount of melatonin secretion, which is likely because of a substantial genetic influence on the levels of melatonin secretion.
本研究的目的是在大量未受光照抑制的完整褪黑素分泌曲线样本中检测个体差异，并寻找褪黑素分泌量和分泌时间与多种生活方式变量之间可能存在的关联。褪黑素分泌曲线来自于85名年龄在18至45岁之间的健康女性和85名健康男性在暗光下每30分钟采集的唾液样本。褪黑素分泌量存在很大的个体差异，峰值范围为2至84皮克/毫升。褪黑素分泌开始时间为18:13至00:26时。使用激素避孕、就业水平降低、固定睡眠时间表的天数减少、白天变长和体重降低与褪黑素分泌幅度增加有关。使用激素避孕、佩戴隐形眼镜、年龄较小以及躁狂和偏执评分较低与褪黑素分泌持续时间较长有关。褪黑素分泌开始时间较早与起床时间较早、晨型人格以及没有同床伴侣有关。生活方式和行为变量仅能解释褪黑素分泌量个体差异的约15%，这可能是因为基因对褪黑素分泌水平有重大影响。
